Institute of Biomolecules Max Mousseron, Department of Artificial Biopolymers, Faculty of Pharmacy, UMR 5247, CNRS-University of Montpellier-ENSCM , Montpellier, France.
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University , Utrecht, The Netherlands.
Biomacromolecules. 2017 Feb 13;18(2):316-330. doi: 10.1021/acs.biomac.6b01604. Epub 2017 Jan 10.
Hydrogels are attractive materials for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. Recent advances in organic and polymer chemistry, bioengineering and nanotechnology have resulted in several new developments in the field of hydrogels for therapeutic delivery. In this Perspective, we present our view on the state-of-the-art in the field, thereby focusing on a number of exciting topics, including bioorthogonal cross-linking methods, multicomponent hydrogels, stimuli-responsive hydrogels, nanogels, and the release of therapeutics from 3D printed hydrogels. We also describe the challenges that should be overcome to facilitate translation from academia to the clinic and last, we share our ideas about the future of this rapidly evolving area of research.
水凝胶因其能够在水膨胀网络中嵌入生物活性物质而成为控制药物释放的有吸引力的材料。有机化学、聚合物化学、生物工程和纳米技术的最新进展导致了治疗性递药领域中水凝胶的若干新发展。在本观点文章中，我们介绍了我们对该领域的最新看法，重点介绍了一些令人兴奋的主题，包括生物正交交联方法、多组分水凝胶、刺激响应水凝胶、纳米凝胶以及 3D 打印水凝胶中治疗剂的释放。我们还描述了为促进从学术界到临床的转化而需要克服的挑战，最后，我们分享了对这一快速发展的研究领域的未来想法。
