†Departamento de Química Orgánica, Facultad de Ciencias y Tecnologías Químicas-IRICA, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain.
§Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
ACS Nano. 2015 May 26;9(5):4686-97. doi: 10.1021/acsnano.5b01433. Epub 2015 May 12.
Considerable progress in the synthesis and technology of hydrogels makes these materials attractive structures for designing controlled-release drug delivery systems. In particular, this review highlights the latest advances in nanocomposite hydrogels as drug delivery vehicles. The inclusion/incorporation of nanoparticles in three-dimensional polymeric structures is an innovative means for obtaining multicomponent systems with diverse functionality within a hybrid hydrogel network. Nanoparticle-hydrogel combinations add synergistic benefits to the new 3D structures. Nanogels as carriers for cancer therapy and injectable gels with improved self-healing properties have also been described as new nanocomposite systems.
水凝胶的合成和技术取得了相当大的进展，使得这些材料成为设计控制释放药物传递系统的有吸引力的结构。特别是，本综述强调了纳米复合水凝胶作为药物传递载体的最新进展。将纳米颗粒纳入三维聚合物结构是在混合水凝胶网络中获得具有多种功能的多组分系统的一种创新手段。纳米颗粒-水凝胶组合为新的 3D 结构增添了协同效益。纳米凝胶作为癌症治疗载体和具有改善的自修复性能的可注射凝胶也被描述为新的纳米复合系统。
