Swanson C A, Levy J A, Morrow W J
Department of Medicine, University of California School of Medicine, San Francisco 94143.
Ann Rheum Dis. 1989 Sep;48(9):765-70. doi: 10.1136/ard.48.9.765.
A diet low in fat was found to retard the development of autoimmune disease in (NZB x NZW)F1 mice, whereas diets high in fat content were associated with more severe disease. The ability of a reduced lipid intake to ameliorate the progression of autoimmune disease was indicated by preserved lacrimal gland secretion (measured by a modified Schirmer test), decreased infiltration of inflammatory cells into the exocrine tissue, and decreased severity of immunohaemolytic anaemia as indicated by near-normal packed cell volume and reticulocyte values. These results suggest that nutritional intervention may be of some help in reducing the severity of pathological abnormalities associated with human systemic lupus erythematosus and Sjögren's syndrome.
研究发现，低脂饮食可延缓（NZB×NZW）F1小鼠自身免疫性疾病的发展，而高脂饮食则与更严重的疾病相关。泪腺分泌得以保留（通过改良的Schirmer试验测量）、炎症细胞向外分泌组织的浸润减少以及免疫性溶血性贫血的严重程度降低（通过接近正常的血细胞比容和网织红细胞值表明），这些都表明减少脂质摄入能够改善自身免疫性疾病的进展。这些结果表明，营养干预可能有助于减轻与人类系统性红斑狼疮和干燥综合征相关的病理异常的严重程度。
