Zhang Minjie, Liang Yichen, Liu Yanbo, Li Yixuan, Shen Long, Shi Guixiu
Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, China.
Front Microbiol. 2022 Jul 22;13:916089. doi: 10.3389/fmicb.2022.916089. eCollection 2022.
Environmental factors are believed to influence the evolution of primary Sjögren's syndrome (pSS). The aims of this study were to investigate the association of pSS with a high-fat diet (HFD) and to relate HFD-induced gut dysbiosis to pSS exacerbation. Male Wild Type (WT) and IL-14α transgenic mice (IL-14α TG) were fed a standard diet (SD) and HFD for 11 months. We found an increase in the autoantibody level, more severe dry eye, severe dry mouth symptoms, and an earlier presence of systemic features in the IL-14α TG mice treated with HFD. These data suggest that HFD can promote the process of pSS in the IL-14α TG mice. In addition, an HFD leads to a decrease in the richness of gut microbiota of IL-14α TG mice treated with HFD. The abundance of was significantly enriched in the IL-14α TG mice treated with HFD compared with other groups. Through the mental test between gut microbiota and clinical parameters, we found that HFD-induced dysbiosis gut microbiota were associated with pSS clinical parameters. In conclusion, HFD results in the aggravation of pSS progression, likely due to the increase of potentially pathogenic microorganisms.
环境因素被认为会影响原发性干燥综合征（pSS）的演变。本研究的目的是调查pSS与高脂饮食（HFD）之间的关联，并将HFD诱导的肠道菌群失调与pSS的加重联系起来。将雄性野生型（WT）和IL-14α转基因小鼠（IL-14α TG）分别给予标准饮食（SD）和HFD喂养11个月。我们发现，接受HFD治疗的IL-14α TG小鼠的自身抗体水平升高、干眼症状更严重、口干症状严重，且全身症状出现得更早。这些数据表明，HFD可促进IL-14α TG小鼠的pSS进程。此外，HFD导致接受HFD治疗的IL-14α TG小鼠肠道微生物群的丰富度降低。与其他组相比，接受HFD治疗的IL-14α TG小鼠中 的丰度显著富集。通过对肠道微生物群与临床参数之间的相关性测试，我们发现HFD诱导的肠道微生物群失调与pSS临床参数相关。总之，HFD导致pSS进展加重，可能是由于潜在致病微生物的增加。
