Golden G S
Ann Neurol. 1978 Aug;4(2):145-8. doi: 10.1002/ana.410040208.
Analysis of the families of 39 unselected children with Tourette syndrome revealed other members with tic disorders in twenty kindreds. In eight families there were 13 individuals with chronic multiple tics, usually motor, not vocal. Twelve different families contained 18 subjects with Tourette syndrome other than the index patient. In three of these families there were 6 additional individuals with chronic motor tics, forming a bridge to the first group. An autosomal dominant mode of inheritance was suggested in all cases. Tourette syndrome and chronic motor tics appear to represent conditions along a continuum and have, in many instances, a hereditary basis.
对39名未经挑选的抽动秽语综合征患儿的家族进行分析后发现，在20个家族中，其他成员也患有抽动障碍。在8个家族中，有13例个体患有慢性多发性抽动，通常为运动性抽动，而非发声性抽动。另有12个不同的家族，除索引患者外，还有18例患有抽动秽语综合征的受试者。在其中3个家族中，还有6例个体患有慢性运动性抽动，从而与第一组病例形成关联。所有病例均提示为常染色体显性遗传模式。抽动秽语综合征和慢性运动性抽动似乎代表了同一连续体上的不同病症，且在许多情况下具有遗传基础。
