抽动秽语综合征的家系研究。
A family study of Gilles de la Tourette syndrome.
作者信息
Pauls D L, Raymond C L, Stevenson J M, Leckman J F
机构信息
Child Study Center, Yale University School of Medicine, New Haven, CT 06510-8009.
出版信息
Am J Hum Genet. 1991 Jan;48(1):154-63.
Previous studies have demonstrated that Gilles de la Tourette syndrome (TS) is a familial disorder and that chronic tics (CT) and obsessive compulsive disorder (OCD) appear to be etiologically related to the syndrome. In the present study we report the results from a study of 338 biological relatives of 86 TS probands, 21 biologically unrelated relatives of adopted TS probands, and 22 relatives of normal subjects. The 43 first-degree relatives of the adopted TS and normal probands constituted a control sample. The rates of TS, CT, and OCD in the total sample of biological relatives of TS probands were significantly greater than in the relatives of controls. In addition, the morbid risks of TS, OCD, and CT were not significantly different in families of probands with OCD when compared to relatives of probands without OCD. These findings provide further evidence that OCD is etiologically related to TS.
以往的研究表明，抽动秽语综合征（TS）是一种家族性疾病，慢性抽动（CT）和强迫症（OCD）在病因上似乎与该综合征相关。在本研究中，我们报告了对86名TS先证者的338名生物学亲属、21名领养TS先证者的无生物学关系亲属以及22名正常受试者亲属的研究结果。领养的TS和正常先证者的43名一级亲属构成了一个对照样本。TS先证者生物学亲属总样本中TS、CT和OCD的发生率显著高于对照组亲属。此外，与无OCD先证者的亲属相比，有OCD先证者家庭中TS、OCD和CT的发病风险没有显著差异。这些发现进一步证明OCD在病因上与TS相关。
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