Azizi-Soleiman Fatemeh, Vafa Mohammadreza, Abiri Behnaz, Safavi Morteza
Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Int J Prev Med. 2016 Dec 5;7:126. doi: 10.4103/2008-7802.195212. eCollection 2016.
Vitamin D is a prohormone nutrient, which is involved in skeletal and extra-skeletal functions. Iron is another essential nutrient that is necessary for the production of red blood cells and oxygen transport. This element plays important roles in enzymatic systems including those required for Vitamin D activation. To the best of our knowledge, there is no exclusive review on the relationship between iron deficiency anemia (IDA), as the most prevalent type of anemia, and Vitamin D deficiency and the effect of recovery from iron deficiency on Vitamin D status. The aim of this study was to conduct a systematic search of observational and clinical trials in this field. The databases of PubMed, ProQuest, Cochrane Library, ISI Web of Knowledge, and SCOPUS were searched comprehensively. English-language human studies conducted on iron deficient patients or interventions on the effect of iron therapy on Vitamin D were extracted ( = 10). Our initial search yielded 938 articles. A total of 23 papers met the inclusion criteria. Thirteen studies were excluded because they were not relevant or not defining anemia types. The final analysis was performed on ten articles (3 cross-sectional and 7 interventional studies). Observational data indicated a positive relationship between iron status and Vitamin D, while trials did not support the effectiveness of iron supplementation on improving Vitamin D status. The mechanism underlying this association may involve the reduction of the activation of hydroxylases that yield calcitriol. Future randomized controlled trials with large sample sizes and proper designs are needed to highlight underlying mechanisms.
维生素D是一种激素原营养素，参与骨骼和骨骼外功能。铁是另一种必需营养素，对于红细胞生成和氧气运输至关重要。这种元素在酶系统中发挥重要作用，包括维生素D活化所需的酶系统。据我们所知，尚无关于最常见的贫血类型——缺铁性贫血（IDA）与维生素D缺乏之间的关系以及缺铁恢复对维生素D状态影响的专门综述。本研究的目的是对该领域的观察性和临床试验进行系统检索。全面检索了PubMed、ProQuest、Cochrane图书馆、ISI知识网络和SCOPUS数据库。提取了对缺铁患者进行的英文人体研究或关于铁疗法对维生素D影响的干预研究（n = 10）。我们的初步检索产生了938篇文章。共有23篇论文符合纳入标准。13项研究被排除，因为它们不相关或未定义贫血类型。对10篇文章（3项横断面研究和7项干预性研究）进行了最终分析。观察数据表明铁状态与维生素D之间存在正相关关系，而试验不支持补充铁对改善维生素D状态的有效性。这种关联的潜在机制可能涉及产生骨化三醇的羟化酶活化的减少。未来需要进行大样本量且设计合理的随机对照试验来突出潜在机制。
