Alfhili Mohammad A, Basudan Ahmed M, Alfaifi Mohammed, Awan Zuhier A, Algethami Mohammed R, Alsughayyir Jawaher
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia.
Life (Basel). 2022 Dec 15;12(12):2119. doi: 10.3390/life12122119.
Emerging evidence suggests an intricate relationship between vitamin D, Ca, and inflammation-driven anemia. We, thus, investigated the patterns of serum 25(OH)D, Ca, ferritin, and iron in healthy and anemic members of the Saudi population.
A population-based, retrospective, cross-sectional study was designed to analyze data for 14,229 subjects, aged 3-110 years, obtained from Al-Borg Medical Laboratories, over a six-year period (2014-2020). Gender and age differences were analyzed for 25(OH)D, Ca, hemoglobin, ferritin, and iron.
Vitamin D deficiency was extremely prevalent (98.47%) irrespective of age or gender, despite an increasing trend with age, in clear contrast to serum Ca. Ferritin was significantly lower in young adult and adult females, compared to elderly females, whereas iron was significantly reduced in females; in particular, adult females compared to young adults or elderly adults. Only anemic adult males had significantly lower 25(OH)D, while Ca was consistently significantly diminished in anemics of all age groups, independent of gender. Notably, hypocalcemic subjects were 2.36 times more likely to be anemic. Moreover, ferritin, but not iron, was significantly diminished in anemics, which was only evident in young adults and adults. However, both ferritin and iron showed positive correlation with hematocrit, hemoglobin, MCH, MCHC, and MCV.
Despite being significantly lower in anemics, 25(OH)D is not particularly associated with anemia, while hypocalcemia is associated with an increased risk for anemia. Assessment of vitamin D and Ca status may be valuable in the clinical management of anemia in the Saudi population.
新出现的证据表明维生素D、钙与炎症驱动的贫血之间存在复杂的关系。因此，我们调查了沙特人群中健康者和贫血者的血清25(OH)D、钙、铁蛋白和铁的模式。
设计了一项基于人群的回顾性横断面研究，以分析在六年期间（2014 - 2020年）从Al-Borg医学实验室获得的14229名年龄在3至110岁受试者的数据。分析了25(OH)D、钙、血红蛋白、铁蛋白和铁在性别和年龄上的差异。
维生素D缺乏极为普遍（98.47%），无论年龄或性别，尽管随年龄有增加趋势，这与血清钙形成鲜明对比。与老年女性相比，年轻成年女性和成年女性的铁蛋白显著较低，而女性的铁显著降低；特别是成年女性与年轻成年人或老年人相比。只有贫血成年男性的25(OH)D显著较低，而所有年龄组的贫血者钙均持续显著降低，与性别无关。值得注意的是，低钙血症患者贫血风险高2.36倍。此外，贫血者中铁蛋白显著降低，但铁没有，这仅在年轻人和成年人中明显。然而，铁蛋白和铁均与血细胞比容、血红蛋白、平均红细胞血红蛋白含量、平均红细胞血红蛋白浓度和平均红细胞体积呈正相关。
尽管贫血者的25(OH)D显著较低，但它与贫血并无特别关联，而低钙血症与贫血风险增加有关。评估维生素D和钙状态可能对沙特人群贫血的临床管理有价值。
