Baek Jong Ha, Jin Sang Man, Bae Ji Cheol, Jee Jae Hwan, Yu Tae Yang, Kim Soo Kyoung, Hur Kyu Yeon, Lee Moon Kyu, Kim Jae Hyeon
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Korea.
Diabetes Metab J. 2017 Feb;41(1):60-68. doi: 10.4093/dmj.2017.41.1.60. Epub 2016 Dec 26.
An association between serum calcium level and risk of metabolic syndrome (MetS) has been suggested in cross-sectional studies. This study aimed to evaluate the association between baseline serum calcium level and risk of incident MetS in a longitudinal study.
We conducted a retrospective longitudinal study of 12,706 participants without MetS who participated in a health screening program, had normal range serum calcium level at baseline (mean age, 51 years), and were followed up for 4.3 years (18,925 person-years). The risk of developing MetS was analyzed according to the baseline serum calcium levels.
A total of 3,448 incident cases (27.1%) of MetS developed during the follow-up period. The hazard ratio (HR) for incident MetS did not increase with increasing tertile of serum calcium level in an age- and sex-matched model (P for trend=0.915). The HRs (95% confidence interval [CI]) for incident MetS comparing the second and the third tertiles to the first tertile of baseline serum calcium level were 0.91 (95% CI, 0.84 to 0.99) and 0.85 (95% CI, 0.78 to 0.92) in a fully adjusted model, respectively (P for trend=0.001). A decreased risk of incident MetS in higher tertiles of serum calcium level was observed in subjects with central obesity and/or a metabolically unhealthy state at baseline.
There was no positive correlation between baseline serum calcium levels and incident risk of MetS in this longitudinal study. There was an association between higher serum calcium levels and decreased incident MetS in individuals with central obesity or two components of MetS at baseline.
横断面研究提示血清钙水平与代谢综合征（MetS）风险之间存在关联。本研究旨在通过纵向研究评估基线血清钙水平与新发MetS风险之间的关联。
我们对12706名无MetS的参与者进行了一项回顾性纵向研究，这些参与者参加了健康筛查项目，基线时血清钙水平在正常范围内（平均年龄51岁），并随访了4.3年（18925人年）。根据基线血清钙水平分析发生MetS的风险。
随访期间共发生3448例（27.1%）新发MetS病例。在年龄和性别匹配模型中，新发MetS的风险比（HR）并未随着血清钙水平三分位数的增加而升高（趋势P=0.915）。在完全调整模型中，将基线血清钙水平的第二和第三三分位数与第一三分位数相比，新发MetS的HR（95%置信区间[CI]）分别为0.91（95%CI，0.84至0.99）和0.85（95%CI，0.78至0.92）（趋势P=0.001）。在基线时患有中心性肥胖和/或代谢不健康状态的受试者中，观察到血清钙水平较高三分位数时新发MetS的风险降低。
在这项纵向研究中，基线血清钙水平与MetS的新发风险之间没有正相关。在基线时患有中心性肥胖或MetS两个组分的个体中，较高的血清钙水平与新发MetS风险降低之间存在关联。
