二甲双胍：拓展应用范围——更早开始，更晚停药。
Metformin: Expanding the Scope of Application-Starting Earlier than Yesterday, Canceling Later.
机构信息
National Almazov Medical Research Centre, Institute of Molecular Biology and Genetics, 197341 Saint-Petersburg, Russia.
出版信息
Int J Mol Sci. 2022 Feb 21;23(4):2363. doi: 10.3390/ijms23042363.
Abstract
Today the area of application of metformin is expanding, and a wealth of data point to its benefits in people without carbohydrate metabolism disorders. Already in the population of people leading an unhealthy lifestyle, before the formation of obesity and prediabetes metformin smooths out the adverse effects of a high-fat diet. Being prescribed at this stage, metformin will probably be able to, if not prevent, then significantly reduce the progression of all subsequent metabolic changes. To a large extent, this review will discuss the proofs of the evidence for this. Another recent important change is a removal of a number of restrictions on its use in patients with heart failure, acute coronary syndrome and chronic kidney disease. We will discuss the reasons for these changes and present a new perspective on the role of increasing lactate in metformin therapy.
摘要
如今，二甲双胍的应用领域正在不断扩大，大量数据表明，它对碳水化合物代谢紊乱人群以外的人群也有好处。在肥胖和糖尿病前期形成之前，二甲双胍就已经能够在生活方式不健康的人群中消除高脂肪饮食的不良影响。在这个阶段开处方，二甲双胍可能不仅能预防，而且还能显著减缓所有后续代谢变化的进展。在很大程度上，这篇综述将讨论为此提供的证据。另一个最近的重要变化是取消了对心力衰竭、急性冠脉综合征和慢性肾病患者使用二甲双胍的一些限制。我们将讨论这些变化的原因，并提出一个关于增加二甲双胍治疗中乳酸作用的新视角。
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