Shinya H, Fujimura M
Nihon Geka Hokan. 1989 Jan 1;58(1):3-17.
The aim of this study was to elucidate whether cholecystokinin (CCK) had a role in the occurrence and/or in the development of experimental acute pancreatitis in rats, and furthermore to find the possibility for the treatment of acute pancreatitis with a CCK antagonist, proglumide. The administration of CCK-8 significantly increased serum levels of amylase, lipase and pancreatic wet weight. The administration of proglumide significantly reduced the blood levels of trypsin, pancreatic wet weight, water content and improved survival rate. These findings were supported by microscopic examination. The results of this study demonstrate that CCK has an important role in the development of acute pancreatitis and that proglumide might have prophylactic and therapeutic effects in acute pancreatitis.
本研究的目的是阐明胆囊收缩素（CCK）在大鼠实验性急性胰腺炎的发生和/或发展中是否起作用，此外还旨在探寻用CCK拮抗剂丙谷胺治疗急性胰腺炎的可能性。给予CCK-8可显著提高血清淀粉酶、脂肪酶水平及胰腺湿重。给予丙谷胺可显著降低胰蛋白酶的血药浓度、胰腺湿重及含水量，并提高存活率。这些发现得到了显微镜检查的支持。本研究结果表明，CCK在急性胰腺炎的发展中起重要作用，丙谷胺可能对急性胰腺炎具有预防和治疗作用。
