Tarpila E, Larsson L, Lilja I, Ihse I
Department of Surgery, University Hospital, Linköping, Sweden.
Int J Pancreatol. 1988 Mar;3(2-3):195-202. doi: 10.1007/BF02798931.
Rats with acute experimental pancreatitis were treated with the cholecystokinin (CCK)-receptor antagonist proglumide. S-amylase was not affected by proglumide during the initial 4 h but was reduced after 72 h as compared to pre-pancreatitis values. The amylase levels in peritoneal fluid were lower in proglumide treated animals at 1, 2, 4 and 72 h after the induction of the pancreatitis, and amylase in pancreatic tissue was increased by proglumide after six but not 72 h. In spite of these biochemical changes, suggesting beneficial therapeutic effects by proglumide, survival rate was not improved when using a dose of 100 mg/kg every 8 h for 48 h and significantly reduced at a dose of 500 mg/kg every 8 h for 48 h. The results do not support proglumide as the sole treatment in acute pancreatitis.
用胆囊收缩素（CCK）受体拮抗剂丙谷胺治疗急性实验性胰腺炎大鼠。在最初4小时内，血清淀粉酶不受丙谷胺影响，但与胰腺炎前的值相比，72小时后降低。在胰腺炎诱导后1、2、4和72小时，丙谷胺治疗的动物腹腔液中的淀粉酶水平较低，胰腺组织中的淀粉酶在6小时后而非72小时后因丙谷胺而升高。尽管这些生化变化表明丙谷胺具有有益的治疗效果，但每8小时给予100mg/kg剂量共48小时时，存活率并未提高，而每8小时给予500mg/kg剂量共48小时时，存活率显著降低。结果不支持将丙谷胺作为急性胰腺炎的唯一治疗方法。
