心脏代谢健康与肌萎缩侧索硬化症风险

Cardiometabolic health and risk of amyotrophic lateral sclerosis.

作者信息

Timmins Hannah C, Saw Wilfred, Cheah Benjamin C, Lin Cindy S Y, Vucic Steve, Ahmed Rebekah M, Kiernan Matthew C, Park Susanna B

机构信息

Brain and Mind Centre, University of Sydney, Level 4, 94 Mallett Street, Camperdown, 2050, Sydney, New South Wales, Australia.

Eastern Heart Clinic, Prince of Wales Hospital, Sydney, New South Wales, Australia.

出版信息

Muscle Nerve. 2017 Oct;56(4):721-725. doi: 10.1002/mus.25547. Epub 2017 Mar 24.

DOI:10.1002/mus.25547

PMID:28029705

Abstract

INTRODUCTION

Patients diagnosed with amyotrophic lateral sclerosis (ALS) generally have a limited medical history and a normal body mass index, raising the possibility of a premorbid ALS phenotype.

METHODS

The prevalence of cardiometabolic factors was analyzed in 58 ALS patients via comprehensive cardiovascular assessments and compared with Australian population norms.

RESULTS

ALS patients had good cardiac fitness and no reported cardiovascular events. Average blood pressure, heart rate, PR interval, and corrected QT interval were in the normal range. There were significantly fewer obese women in the ALS cohort (13.6%, P < 0.05) and more men with a normal body mass index than in the general population (47.2%, P < 0.001). The percentage of individuals who had never smoked was greater for the ALS cohort (55.8%, P ≤ 0.001), and the prevalence of dyslipidemia was lower (38.7%) compared with the general population (74.4%, P < 0.001).

CONCLUSION

ALS patients had good cardiometabolic health, with evidence of a reduced vascular risk profile. Muscle Nerve 56: 721-725, 2017.

摘要

引言

被诊断为肌萎缩侧索硬化症（ALS）的患者通常病史有限且体重指数正常，这增加了病前存在ALS表型的可能性。

方法

通过全面的心血管评估分析了58例ALS患者中心血管代谢因素的患病率，并与澳大利亚人群标准进行比较。

结果

ALS患者心脏功能良好，未报告心血管事件。平均血压、心率、PR间期和校正QT间期均在正常范围内。与一般人群相比，ALS队列中的肥胖女性显著更少（13.6%，P < 0.05），体重指数正常的男性更多（47.2%，P < 0.001）。ALS队列中从不吸烟的个体百分比更高（55.8%，P ≤ 0.001），血脂异常的患病率更低（38.7%），而一般人群为（74.4%，P < 0.001）。