a Department of Neurology , West China Hospital, Sichuan University , Chengdu , Sichuan Province , P.R. China.
b Department of Neurology , Seventh People's Hospital of Chengdu , Chengdu , Sichuan Province , P.R. China.
Amyotroph Lateral Scler Frontotemporal Degener. 2019 Aug;20(5-6):356-367. doi: 10.1080/21678421.2019.1587631. Epub 2019 Apr 1.
Studies have suggested that obesity is associated with better prognosis among individuals with various types of neurodegenerative diseases, and while some studies suggest that the same is true of amyotrophic lateral sclerosis (ALS), other works cast doubt on this conclusion. Therefore, we conducted a meta-analysis to systematically evaluate the role of body mass index in the prognosis of ALS. PubMed was systematically searched to identify eligible articles, and data on long-term survival were meta-analyzed in terms of hazard ratios (HR) with corresponding 95% confidence intervals (CI). Level of heterogeneity among studies and publication bias were estimated. A total of 17 studies with 9991 ALS patients were included in the review. Each increase of 1 kg/m in body mass index was associated with significantly better long-term overall survival (HR 0.95, 95%CI 0.93-0.97; < 0.001). Obesity may also be a strong predictor of favorable long-term prognosis (HR 0.73; 95%CI 0.62-0.86; < 0.001). Our results suggest that higher body mass index and obesity are associated with better long-term survival of ALS patients.
研究表明，肥胖与各种类型的神经退行性疾病患者的预后较好有关，虽然一些研究表明肌萎缩侧索硬化症（ALS）也是如此，但其他研究对这一结论提出了质疑。因此，我们进行了一项荟萃分析，以系统评估体重指数在 ALS 预后中的作用。系统地检索了 PubMed 以确定合格的文章，并根据风险比（HR）及其相应的 95%置信区间（CI），对长期生存数据进行荟萃分析。估计了研究之间的异质性水平和发表偏倚。共有 17 项研究纳入了 9991 名 ALS 患者。体重指数每增加 1kg/m，与长期总体生存率显著提高相关（HR 0.95，95%CI 0.93-0.97； < 0.001）。肥胖也可能是良好长期预后的有力预测因素（HR 0.73；95%CI 0.62-0.86； < 0.001）。我们的结果表明，较高的体重指数和肥胖与 ALS 患者的长期生存更好相关。
