Case Series Description and Genomic Characterization of Invasive Group A Streptococcal Infections in Pediatric Patients.

作者信息

Dien Bard Jennifer, Mongkolrattanothai Kanokporn, Kachroo Priyanka, Beres Stephen, Olsen Randall J

机构信息

From the *Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California; †Keck School of Medicine at the University of Southern California, Los Angeles, California; ‡Division of Infectious Diseases, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California; §Center for Molecular and Translational Human Infectious Diseases Research; and ¶Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.

出版信息

Pediatr Infect Dis J. 2017 Jun;36(6):618-620. doi: 10.1097/INF.0000000000001519.

DOI:10.1097/INF.0000000000001519

PMID:28030528

Abstract

We report an unusual cluster of invasive group A Streptococcus infections in 6 pediatric patients and demonstrate that the strains were derived from diverse genetic backgrounds, confirming the occurrence of a community cluster rather than a clonal outbreak. Whole genome sequencing provided a rapid and comprehensive view of group A Streptococcus genotypes and helped guide our institutional response and public health maneuvers.

摘要