Beatty W W, Goodkin D E, Monson N, Beatty P A
Clinical Neuroscience Research Program, Neuropsychiatric Research Institute, Fargo, ND.
Arch Neurol. 1989 Oct;46(10):1113-9. doi: 10.1001/archneur.1989.00520460103020.
The performance of 42 patients with relapsing remitting (RR) multiple sclerosis was compared with that of 24 age-, education-, and gender-matched control subjects on a battery of neuropsychological tests known from previous studies to be sensitive to the impairments of patients with chronic progressive (CP) multiple sclerosis. Like CP patients, RR patients exhibited deficits on tests of information-processing speed, verbal fluency, and problem solving, and on recall measures of anterograde and remote memory. Although a few patients were mildly dysnomic, the RR patients were not generally impaired on visual confrontation naming and they did not exhibit perseverative responding on verbal fluency measures. The pattern of neuropsychological deficits exhibited by RR patients closely approximates the profile observed in other subcortical dementias and does not contain the features of cortical dementia evident in some CP patients. The impairment of RR patients on cognitive tests were less severe than those observed in CP patients in our previous studies. Differences in the age of patients in the CP and RR groups did not account for group differences in the severity of cognitive impairments, but differences in disease duration or severity of disability, as well as disease course, could explain why CP patients exhibit more serious cognitive disturbances than RR patients.
在一系列先前研究中已知对慢性进展型（CP）多发性硬化症患者的损伤敏感的神经心理学测试中，对42例复发缓解型（RR）多发性硬化症患者的表现与24名年龄、教育程度和性别相匹配的对照受试者的表现进行了比较。与CP患者一样，RR患者在信息处理速度、语言流畅性和问题解决测试以及顺行性和远距记忆的回忆测量方面表现出缺陷。虽然少数患者存在轻度构音障碍，但RR患者在视觉对名称测试中一般没有受损，并且在语言流畅性测量中也没有表现出持续性反应。RR患者表现出的神经心理学缺陷模式与在其他皮质下痴呆中观察到的情况非常相似，并且不包含一些CP患者中明显的皮质痴呆特征。RR患者在认知测试中的损伤不如我们先前研究中观察到的CP患者严重。CP组和RR组患者的年龄差异并不能解释认知损伤严重程度的组间差异，但疾病持续时间、残疾严重程度以及病程的差异可以解释为什么CP患者比RR患者表现出更严重的认知障碍。
