Fishman G A, Gilbert L D, Fiscella R G, Kimura A E, Jampol L M
Department of Ophthalmology, University of Illinois, Chicago 60612.
Arch Ophthalmol. 1989 Oct;107(10):1445-52. doi: 10.1001/archopht.1989.01070020519031.
Twelve patients with retinitis pigmentosa and chronic macular edema were prospectively treated for 2-week periods with acetazolamide or a placebo in a masked, crossover study. Ten of the 12 patients had both subjective and objective improvement in visual acuity when treated with acetazolamide. Improvement was seen even in patients with an acuity as good as 20/25 at baseline as well as in patients with macular edema present for more than a decade. A dosage of 500 mg/d was found to be more effective than 250 mg/d. Six patients (50%) showed lessening of their macular edema on fluorescein angiography. This angiographically demonstrated improvement was predominantly due to less detectable leakage from retinal capillaries rather than from choroidal capillaries through the retinal pigment epithelium. Improvement in visual acuity was seen in some patients without a detectable change in the amount of angiographic fluorescein leakage.
在一项双盲交叉研究中，对12例患有色素性视网膜炎和慢性黄斑水肿的患者进行了为期2周的乙酰唑胺或安慰剂治疗。12例患者中有10例在接受乙酰唑胺治疗后视力有主观和客观改善。即使是基线视力高达20/25的患者以及黄斑水肿存在超过十年的患者也出现了改善。发现500mg/d的剂量比250mg/d更有效。6例患者（50%）在荧光素血管造影上显示黄斑水肿减轻。血管造影显示的这种改善主要是由于视网膜毛细血管渗漏减少，而非脉络膜毛细血管通过视网膜色素上皮的渗漏减少。一些患者视力改善，但血管造影荧光素渗漏量无明显变化。
