Al-Drawi Abu-Sitta, Wiciński Michał, Grześk Grzegorz, Szadujkis-Szadurska Katarzyna, Grześk Elżbieta, Węclewicz Mateusz Maciej, Michalska Agnieszka, Czeczuk Anna, Huk-Wieliczuk Elżbieta
Department of Neurosurgery and Neurotraumatology, University Hospital No. 2, Bydgoszcz, Poland.
Department of Pharmacology and Therapeutics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz.
Ann Agric Environ Med. 2016 Dec 23;23(4):654-659. doi: 10.5604/12321966.1226862.
The term 'subarachnoid haemorrhage' (SAH) stands for bleeding into the subarachnoid space, regardless of its source. It may be of primary character when the source of bleeding is situated within the subarachnoid space. Subarachnoid haemorrhage is often described as spontaneous bleeding, mainly in order to differentiate it from post-traumatic bleeding.
The aim of the study was to evaluate the concentration of ICAM-1 and VCAM-1 in the blood of patients in the early phase following subarachnoid haemorrhage in terms of searching for markers useful in subarachnoid bleeding diagnostics and monitoring a patient's clinical state.
The study comprised 85 patients (47 women, 38 men), aged 29-81 (average 53±12 years), suffering from subarachnoid haemorrhage. The control group comprised 45 healthy people selected according to gender and age corresponding with the experimental group.
The study revealed that the concentration of ICAM-1 and VCAM-1 was significantly higher in patients suffering from subarachnoid haemorrhage. Additionally, the concentration of fibrinogen decreased, aPTT was shorter and the concentration of D-dimers increased. The studied parameters did not differ with respect to the age or gender of the patients. It was stated that according to the Hunt and Hess scale, the concentration of ICAM-1 was considerably higher in the group of patients in the most severe neurological state, compared to other patients. It was also observed that the concentration of fibrinogen was significantly higher, aPTT was shorter, and the concentration of D-dimers increased in the afore-mentioned group.
Evaluation of the concentration of adhesion molecules, as well as values of global tests concerning the coagulation system, may serve as a useful diagnostic tool for SAH.
“蛛网膜下腔出血”（SAH）这一术语指的是血液流入蛛网膜下腔，无论其来源如何。当出血源位于蛛网膜下腔内时，它可能具有原发性特征。蛛网膜下腔出血通常被描述为自发性出血，主要是为了将其与创伤后出血区分开来。
本研究的目的是评估蛛网膜下腔出血早期患者血液中ICAM - 1和VCAM - 1的浓度，以寻找有助于蛛网膜下腔出血诊断和监测患者临床状态的标志物。
该研究包括85例年龄在29 - 81岁（平均53±12岁）的蛛网膜下腔出血患者（47名女性，38名男性）。对照组包括45名根据性别和年龄与实验组相匹配的健康人。
研究表明，蛛网膜下腔出血患者中ICAM - 1和VCAM - 1的浓度显著更高。此外，纤维蛋白原浓度降低，活化部分凝血活酶时间缩短，D - 二聚体浓度升高。所研究的参数在患者的年龄或性别方面没有差异。据指出，根据Hunt和Hess量表，与其他患者相比，处于最严重神经状态的患者组中ICAM - 1的浓度要高得多。还观察到，上述组中纤维蛋白原浓度显著更高，活化部分凝血活酶时间更短，D - 二聚体浓度升高。
评估黏附分子的浓度以及凝血系统的整体检测值，可能是SAH的一种有用诊断工具。
