Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 9 Sklodowskiej-Curie Street, Bydgoszcz, Poland.
Department of Neurosurgery and Neurotraumatology, University Hospital No. 2 in Bydgoszcz, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 75 Biziel Street, Bydgoszcz, Poland.
Biomed Res Int. 2019 Jul 8;2019:8759231. doi: 10.1155/2019/8759231. eCollection 2019.
Subarachnoid hemorrhage (SAH) is currently one of the most serious diseases of the central nervous system. To reduce the negative consequences of SAH and help clinicians to assess the patient's condition, there are attempts to search for new diagnostic markers, which quickly and accurately allow for the proper diagnosis. The aim of this research was the concentration and activity of Vascular Endothelial Growth Factor A (VEGF-A) and selected parameters of coagulation and fibrinolysis in the blood of patients with SAH. Serum levels of VEGF-A in patients diagnosed with SAH are measured to assess the correlation between VEGF-A and the clinical condition of patient. This may help with proper therapeutics and better prognosis. The study involved 85 patients with subarachnoid hemorrhage. The control group consisted of 45 healthy subjects, sex and age matched. The following parameters were determined: APTT (Activated Partial Thromboplastin Time), INR (International Normalized Ratio), D-dimers and fibrinogen concentration, and the concentration of VEGF-A by ELISA (R&D USA). The average concentration of VEGF-A in the study group was significantly lower compared to the control group. The D-dimer concentration was higher in patients with SAH but the difference was not significant. Coagulation parameters such as INR, APTT, and fibrinogen did not show significant differences between investigated groups. VEGF-A cannot be an independent marker of SAH. Selected parameters of coagulation and fibrinolysis such as D-dimers, INR, APTT, and fibrinogen should not be used as markers of SAH.
蛛网膜下腔出血（SAH）是目前中枢神经系统最严重的疾病之一。为了降低 SAH 的负面影响并帮助临床医生评估患者的病情，人们试图寻找新的诊断标志物，这些标志物能快速、准确地做出正确诊断。本研究的目的是检测蛛网膜下腔出血患者血液中血管内皮生长因子 A（VEGF-A）的浓度和活性，以及部分凝血和纤溶参数。通过测量诊断为 SAH 的患者的血清 VEGF-A 水平，评估 VEGF-A 与患者临床状况之间的相关性。这可能有助于进行适当的治疗和改善预后。本研究共纳入 85 例蛛网膜下腔出血患者。对照组为 45 例性别和年龄匹配的健康受试者。测定了以下参数：APTT（活化部分凝血活酶时间）、INR（国际标准化比值）、D-二聚体和纤维蛋白原浓度，以及 ELISA（R&D USA）法检测的 VEGF-A 浓度。与对照组相比，研究组的 VEGF-A 平均浓度明显降低。SAH 患者的 D-二聚体浓度较高，但差异无统计学意义。INR、APTT 和纤维蛋白原等凝血参数在两组间无显著差异。VEGF-A 不能作为 SAH 的独立标志物。D-二聚体、INR、APTT 和纤维蛋白原等部分凝血和纤溶参数不应作为 SAH 的标志物。
