亚洲国家出现产超广谱β-内酰胺酶的肺炎克雷伯菌血清型K1 ST23菌株。
Emergence of an extended-spectrum β-lactamase-producing serotype K1 Klebsiella pneumoniae ST23 strain from Asian countries.
作者信息
Cheong H S, Chung D R, Park M, Kim S H, Ko K S, Ha Y E, Kang C I, Peck K R, Song J H
机构信息
Division of Infectious Diseases,Konkuk University Hospital, Konkuk University School of Medicine,Seoul,Korea.
Division of Infectious Diseases,Samsung Medical Centre, Sungkyunkwan University School of Medicine,Seoul,Korea.
出版信息
Epidemiol Infect. 2017 Apr;145(5):990-994. doi: 10.1017/S0950268816003113. Epub 2016 Dec 29.
Abstract
Extended-spectrum β-lactamase (ESBL) production has been very rare in serotype K1 Klebsiella pneumoniae ST23 strains, which are well-known invasive community strains. Among 92 ESBL-producing strains identified in 218 isolates from nine Asian countries, serotype K1 K. pneumoniae strains were screened. Two ESBL-producing K. pneumoniae isolates from Singapore and Indonesia were determined to be serotype K1 and ST23. Their plasmids, which contain CTX-M-15 genes, are transferable rendering the effective transfer of ESBL resistance plasmids to other organisms.
摘要
超广谱β-内酰胺酶（ESBL）在肺炎克雷伯菌ST23菌株血清型K1中产生的情况非常罕见，而肺炎克雷伯菌ST23菌株是著名的侵袭性社区菌株。在从9个亚洲国家的218株分离菌中鉴定出的92株产ESBL菌株中，对肺炎克雷伯菌血清型K1菌株进行了筛查。来自新加坡和印度尼西亚的两株产ESBL肺炎克雷伯菌分离株被确定为血清型K1和ST23。它们含有CTX-M-15基因的质粒是可转移的，这使得ESBL耐药质粒能够有效地转移到其他生物体中。
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