澳大利亚粪肠球菌中vanA基因介导的耐万古霉素肠球菌的多克隆出现
Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia.
作者信息
van Hal Sebastiaan J, Espedido Björn A, Coombs Geoffrey W, Howden Benjamin P, Korman Tony M, Nimmo Graeme R, Gosbell Iain B, Jensen Slade O
机构信息
School of Medicine, Western Sydney University, Sydney, NSW, Australia.
Royal Prince Alfred Hospital, Sydney, NSW, Australia.
出版信息
J Antimicrob Chemother. 2017 Apr 1;72(4):998-1001. doi: 10.1093/jac/dkw539.
OBJECTIVES
To investigate the genetic context associated with the emergence of vanA VRE in Australia.
METHODS
The whole genomes of 18 randomly selected vanA -positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed.
RESULTS
In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn 1546 variants and plasmid backbone structures.
CONCLUSIONS
The recent emergence of vanA VRE in Australia was polyclonal and not associated with the dissemination of a single 'dominant' ST or vanA -encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources.
目的
研究与澳大利亚vanA屎肠球菌（VRE）出现相关的遗传背景。
方法
对2011年至2013年间从澳大利亚四个首府城市的医院随机选取的18株vanA阳性屎肠球菌患者分离株的全基因组进行测序和分析。
结果
电子分型和转座子/质粒组装显示，测序的分离株（在大多数情况下）代表不同的医院适应性序列类型（STs），并与多种不同的Tn1546变体和质粒骨架结构相关。
结论
澳大利亚近期vanA VRE的出现是多克隆的，与单一“优势”ST或vanA编码质粒的传播无关。有趣的是，导致这种流行病学变化的因素尚不清楚，未来的研究可能需要考虑调查潜在的社区来源。
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