Rogers Lindsay A, Strong Kayla, Cork Susan C, McAllister Tim A, Liljebjelke Karen, Zaheer Rahat, Checkley Sylvia L
Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada.
Front Public Health. 2021 Jun 10;9:599285. doi: 10.3389/fpubh.2021.599285. eCollection 2021.
spp. have arisen as important nosocomial pathogens and are ubiquitous in the gastrointestinal tracts of animals and the environment. They carry many intrinsic and acquired antimicrobial resistance genes. Because of this, surveillance of spp. has become important with whole genome sequencing emerging as the preferred method for the characterization of enterococci. A scoping review was designed to determine how the use of whole genome sequencing in the surveillance of spp. adds to our knowledge of antimicrobial resistance in spp. Scoping review design was guided by the PRISMA extension and checklist and JBI Reviewer's Guide for scoping reviews. A total of 72 articles were included in the review. Of the 72 articles included, 48.6% did not state an association with a surveillance program and 87.5% of articles identified . The majority of articles included isolates from human clinical or screening samples. Significant findings from the articles included novel sequence types, the increasing prevalence of vancomycin-resistant enterococci in hospitals, and the importance of surveillance or screening for enterococci. The ability of enterococci to adapt and persist within a wide range of environments was also a key finding. These studies emphasize the importance of ongoing surveillance of enterococci from a One Health perspective. More studies are needed to compare the whole genome sequences of human enterococcal isolates to those from food animals, food products, the environment, and companion animals.
[具体菌名]已成为重要的医院感染病原体，在动物胃肠道和环境中广泛存在。它们携带许多固有和获得性抗菌耐药基因。因此，随着全基因组测序成为肠球菌特征鉴定的首选方法，对[具体菌名]的监测变得至关重要。一项范围综述旨在确定全基因组测序在[具体菌名]监测中的应用如何增加我们对[具体菌名]抗菌耐药性的了解。范围综述设计以PRISMA扩展和清单以及JBI范围综述审稿人指南为指导。该综述共纳入72篇文章。在纳入的72篇文章中，48.6%未说明与监测项目的关联，87.5%的文章鉴定出[相关内容]。大多数文章纳入了来自人类临床或筛查样本的分离株。文章的重要发现包括新的序列类型、医院中耐万古霉素肠球菌患病率的增加以及对肠球菌进行监测或筛查的重要性。肠球菌在广泛环境中适应和持续存在的能力也是一项关键发现。这些研究强调了从“同一健康”角度持续监测肠球菌的重要性。需要更多研究来比较人类肠球菌分离株与来自食用动物、食品、环境和伴侣动物的全基因组序列。
