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乔治·贝利谈肽阵列,一项改变磷酸二酯酶研究的技术。

George Baillie on peptide array, a technique that transformed research on phosphodiesterases.

作者信息

Baillie George S

机构信息

Institute of Cardiovascular and Medical Sciences, CMVLS, Glasgow University, Glasgow, UK.

出版信息

Future Sci OA. 2015 Nov 1;1(3):FSO27. doi: 10.4155/fso.15.25. eCollection 2015 Nov.

Abstract

George Baillie is a Professor and PI within the Institute of Cardiovascular and Medical Sciences at the University of Glasgow (Glasgow, UK). His research over the last 15 years has examined many aspects of the cAMP signaling pathway in disease and he has published over 140 papers on the subject. His major discovery was that phosphodiesterases are 'compartmentalized', and it is their location within cells that direct their function. The Baillie/Houslay laboratory was the first to discover a specific function for a single isoform of PDE4 (namely PDE4D5 with β-arrestin desensitizes the β2-adrenergic receptor). His laboratory has since gone on to ascribe functions to several other PDE4 isoforms. He is a founder and director of Sannox Therapeutics, a spin-out venture within University of Glasgow. He is also a member of the Editorial Board of .

摘要

乔治·贝利是英国格拉斯哥大学心血管与医学科学研究所的教授及首席研究员。在过去15年里,他的研究涉及疾病中cAMP信号通路的诸多方面,并且已就该主题发表了140多篇论文。他的主要发现是磷酸二酯酶是“分隔化的”,正是它们在细胞内的位置决定了其功能。贝利/豪斯利实验室是首个发现PDE4单一亚型特定功能的(即PDE4D5与β-抑制蛋白可使β2-肾上腺素能受体脱敏)。自那以后,他的实验室继续赋予其他几种PDE4亚型功能。他是Sannox Therapeutics公司的创始人兼董事,该公司是格拉斯哥大学的一家衍生企业。他还是《 》编辑委员会的成员。

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