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荧光素钠引导下脑脓肿手术:一例报告。

Fluorescein sodium-guided surgery of a brain abscess: A case report.

作者信息

Höhne Julius, Brawanski Alexander, Schebesch Karl-Michael

机构信息

Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany.

出版信息

Surg Neurol Int. 2016 Dec 5;7(Suppl 39):S955-S957. doi: 10.4103/2152-7806.195234. eCollection 2016.

DOI:10.4103/2152-7806.195234
PMID:28031990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5180436/
Abstract

BACKGROUND

Up to now, the feasibility and benefit of using fluorescein sodium under a dedicated surgical microscope filter (YE560, YELLOW 560 nm filter, Carl Zeiss Meditec, Germany) has never been clinically evaluated in infectious disorders of the brain.

CASE DESCRIPTION

Here, we report the case of a male patient with a brain abscess in the right parietal lobe that was removed under fluorescence-guidance (intravenous administration of fluorescein sodium 10%, 5 mg/kg bodyweight). The abscess capsule showed intensive yellow fluorescent staining, while - under white light - the cortex appeared normal.

CONCLUSION

This technique may improve the identification and surgical removal of brain abscesses.

摘要

背景

迄今为止,在专用手术显微镜滤光片(YE560,黄色560纳米滤光片,德国卡尔蔡司医疗技术公司)下使用荧光素钠的可行性和益处从未在脑部感染性疾病中进行过临床评估。

病例描述

在此,我们报告一例右侧顶叶脑脓肿男性患者的病例,该脓肿在荧光引导下(静脉注射10%荧光素钠,5毫克/千克体重)被切除。脓肿包膜呈现强烈的黄色荧光染色,而在白光下,皮层看起来正常。

结论

该技术可能会改善脑脓肿的识别和手术切除。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70cd/5180436/5740b817ed9e/SNI-7-955-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70cd/5180436/15af3f9c41f8/SNI-7-955-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70cd/5180436/89a45ff2cbbe/SNI-7-955-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70cd/5180436/5740b817ed9e/SNI-7-955-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70cd/5180436/15af3f9c41f8/SNI-7-955-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70cd/5180436/89a45ff2cbbe/SNI-7-955-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70cd/5180436/5740b817ed9e/SNI-7-955-g003.jpg

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本文引用的文献

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Fluorescein Sodium-Guided Surgery of Malignant Brain Tumors: History, Current Concepts, and Future Project.荧光素钠引导下的恶性脑肿瘤手术:历史、当前概念及未来规划
Turk Neurosurg. 2016;26(2):185-94. doi: 10.5137/1019-5149.JTN.16952-16.0.
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Prospective evaluation of the utility of intraoperative confocal laser endomicroscopy in patients with brain neoplasms using fluorescein sodium: experience with 74 cases.使用荧光素钠对脑肿瘤患者进行术中共聚焦激光内镜检查效用的前瞻性评估:74例经验
Neurosurg Focus. 2016 Mar;40(3):E11. doi: 10.3171/2016.1.FOCUS15559.
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Characterization of the blood-brain barrier of metastatic and primary malignant neoplasms.
转移瘤和原发性恶性肿瘤的血脑屏障特征。
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Science. 1947 Aug 8;106(2745):130-1. doi: 10.1126/science.106.2745.130-a.
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