Rodríguez-Campello A, Jiménez-Conde J, Ois Á, Cuadrado-Godia E, Giralt-Steinhauer E, Vivanco R M, Soriano-Tárraga C, Subirana I, Muñoz D, Gómez-González A, Puig-Pijoan A, Roquer J
Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona.
Neurovascular Research Group, Department of Neurology, IMIM-Hospital del Mar, Barcelona.
Eur J Neurol. 2017 Feb;24(2):397-403. doi: 10.1111/ene.13216. Epub 2016 Dec 29.
The objective of our study was to evaluate sex differences in the impact of weight and abdominal obesity on the risk of ischemic stroke.
We included 388 patients with ischemic stroke (aged <75 years) assessed consecutively in our hospital and 732 controls matched by age and sex. Vascular risk factors and anthropometric data (waist circumference, weight and height) were recorded. The impact of three anthropometric variables [body mass index (BMI), waist circumference and waist to height ratio] on ischemic stroke risk was calculated. These variables were divided into quartiles for a comprehensive comparison between cases and controls, stratified by sex and adjusted in logistic regression by age and vascular risk factors. Further logistic regression using dummy variables was performed to evaluate the association between BMI-adjusted abdominal obesity and stroke risk.
Increased BMI was not associated with increased stroke risk overall or in women, but was a protective factor in men [P = 0.03; odds ratio (OR), 0.59 (0.37-0.94)]. Abdominal obesity was a risk factor for stroke in women, in both waist circumference [P < 0.001; OR, 5.79 (3.10-10.85)] and waist to height ratio [P < 0.001; OR, 3.61 (1.99-6.54)] analyses, but was not significant in men. When considered independently of BMI, abdominal obesity was a risk factor in both sexes, but the strength of the association was significantly higher in women.
Increased BMI was related to a lower risk of stroke in men. Abdominal obesity was associated with ischemic stroke in women. The impact of abdominal obesity on stroke risk differs by sex.
我们研究的目的是评估体重和腹部肥胖对缺血性中风风险影响中的性别差异。
我们纳入了388例在我院连续接受评估的年龄小于75岁的缺血性中风患者以及732例按年龄和性别匹配的对照者。记录血管危险因素和人体测量数据（腰围、体重和身高）。计算三个人体测量变量[体重指数（BMI）、腰围和腰高比]对缺血性中风风险的影响。这些变量被分为四分位数，以便在病例组和对照组之间进行全面比较，按性别分层，并在逻辑回归中按年龄和血管危险因素进行调整。使用虚拟变量进行进一步的逻辑回归，以评估BMI调整后的腹部肥胖与中风风险之间的关联。
总体而言，BMI升高与中风风险增加无关，在女性中也是如此，但在男性中是一个保护因素[P = 0.03；比值比（OR），0.59（0.37 - 0.94）]。腹部肥胖是女性中风的危险因素，在腰围分析[P < 0.001；OR，5.79（3.10 - 10.85）]和腰高比分析[P < 0.001；OR，3.61（1.99 - 6.54）]中均是如此，但在男性中不显著。当独立于BMI考虑时，腹部肥胖在两性中都是危险因素，但女性的关联强度显著更高。
BMI升高与男性中风风险降低有关。腹部肥胖与女性缺血性中风有关。腹部肥胖对中风风险的影响存在性别差异。
