Digital Health Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong‑daero, Yuseong‑gu, Daejeon, 34054, Republic of Korea.
Sci Rep. 2023 Feb 20;13(1):2948. doi: 10.1038/s41598-023-29902-4.
Stroke is strongly associated with death and disability. However, the associations between stroke and lipid profiles such as total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), and red blood cells (RBCs) and anthropometric indices such as waist circumference and waist-to-height ratio (WHtR) remain unclear. The objective of this study was to investigate these relationships in a Korean population. This large-scale cross-sectional study included data from 38,190 subjects collected from 2010 to 2018 by the Korea National Health and Nutrition Examination Survey (KNHANES). Simple logistic regression models and multiple logistic regression models were used to evaluate the association of stroke with lipid profiles and anthropometric indices in the crude model, adjusted Model 1, and fully adjusted Model 2. In men, stroke was negatively associated with height, weight, and hematocrit level. Total cholesterol and triglycerides were strongly negatively associated with stroke in Model 2. Creatinine level and stroke were weakly associated. Additionally, height, weight, total cholesterol, triglycerides, and hematocrit and creatinine levels were associated with stroke both before and after adjustment. In women, in Model 2, stroke was positively associated with height, weight, and creatinine level. A strong negative association was found between total cholesterol and stroke. Stroke was negatively associated with hemoglobin level, hematocrit level, and RBCs. Additionally, total cholesterol, hemoglobin level, hematocrit level, creatinine level, and RBCs were associated with stroke both before and after adjustment. Weight and height were more closely associated with stroke than waist circumference and WHtR in Korean men. Our results suggested that the association of stroke with triglycerides, height, and weight differed according to sex and that HDL-C was not associated with stroke in people of either sex.
中风与死亡和残疾密切相关。然而，中风与总胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-C）和红细胞（RBC）等血脂以及腰围和腰高比（WHtR）等人体测量指数之间的关联尚不清楚。本研究的目的是在韩国人群中研究这些关系。这项大规模的横断面研究包括 2010 年至 2018 年韩国国家健康和营养检查调查（KNHANES）收集的 38190 名受试者的数据。简单逻辑回归模型和多逻辑回归模型用于评估中风与血脂谱和人体测量指数在粗模型、调整后的模型 1 和完全调整后的模型 2中的关联。在男性中，中风与身高、体重和红细胞压积水平呈负相关。总胆固醇和甘油三酯与中风在模型 2中呈强烈负相关。肌酐水平与中风呈弱相关。此外，身高、体重、总胆固醇、甘油三酯和红细胞压积和肌酐水平在调整前后均与中风相关。在女性中，在模型 2 中，中风与身高、体重和肌酐水平呈正相关。总胆固醇与中风呈强烈负相关。中风与血红蛋白水平、红细胞压积水平和 RBC 呈负相关。此外，总胆固醇、血红蛋白水平、红细胞压积水平、肌酐水平和 RBC 水平在调整前后均与中风相关。在韩国男性中，体重和身高与中风的相关性强于腰围和 WHtR。我们的结果表明，中风与甘油三酯、身高和体重的相关性因性别而异，并且 HDL-C 与男女的中风无关。
