Sharma Jitender, Gondalia Shrey, Sharma Neetu
Neurology, Army Base Hospital, New Delhi, IND.
Medicine, Jagruti Hospital, Jamnagar, IND.
Cureus. 2025 Jun 20;17(6):e86464. doi: 10.7759/cureus.86464. eCollection 2025 Jun.
The present systematic review aims to compare ischemic stroke outcomes in patients with and without metabolic syndrome. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline was followed during the conduct of this systematic review. The literature search encompassed extensive databases like PubMed, MEDLINE, ScienceDirect, and Cochrane Library. We included studies published between 2014 and 2024 in the English language that fulfilled inclusion and exclusion criteria. The quality of the included studies was assessed using appropriate tools tailored to the study design. The synthesis and analysis of data included a narrative summary of study characteristics, outcomes assessed, and main findings. The analyzed results demonstrate a multifaceted connection between metabolic syndrome and the outcomes of ischemic stroke. While several studies affirm that specific components of metabolic syndrome (MetS), notably hyperglycemia, hypertension, and waist circumference, are associated with increased risk and poor outcomes, the role of broader metabolic health appears nuanced. Some studies highlight that metabolic status (not solely weight or BMI) is paramount in predicting both acute events like early neurological deterioration (END) and recurrent strokes, suggesting tailored interventions focusing on metabolic health could enhance patient outcomes. This systematic review concluded that the risk of stroke and poor outcomes increased with the number of metabolic syndrome components like hypertension, elevated abdominal fat, and hyperglycemia.
本系统评价旨在比较有无代谢综合征患者的缺血性卒中结局。本系统评价遵循系统评价与Meta分析的首选报告项目（PRISMA）指南。文献检索涵盖了如PubMed、MEDLINE、ScienceDirect和Cochrane图书馆等广泛的数据库。我们纳入了2014年至2024年间发表的符合纳入和排除标准的英文研究。使用根据研究设计定制的适当工具评估纳入研究的质量。数据的综合和分析包括对研究特征、评估的结局和主要发现的叙述性总结。分析结果表明代谢综合征与缺血性卒中结局之间存在多方面的联系。虽然多项研究证实代谢综合征（MetS）的特定组成部分，尤其是高血糖、高血压和腰围，与风险增加和不良结局相关，但更广泛的代谢健康的作用似乎较为微妙。一些研究强调，代谢状态（不仅仅是体重或BMI）在预测早期神经功能恶化（END）和复发性卒中等急性事件方面至关重要，这表明针对代谢健康的定制干预措施可能会改善患者结局。本系统评价得出结论，卒中风险和不良结局会随着高血压、腹部脂肪增加和高血糖等代谢综合征组成部分数量的增加而升高。
