精神分裂症中的认知障碍与代谢综合征之间的关系：一项系统评价和荟萃分析。
The relationship between cognitive impairment in schizophrenia and metabolic syndrome: a systematic review and meta-analysis.
作者信息
Bora E, Akdede B B, Alptekin K
机构信息
Department of Psychiatry,Melbourne Neuropsychiatry Centre,University of Melbourne and Melbourne Health,Carlton South,Victoria,Australia.
Department of Psychiatry,Dokuz Eylul University School of Medicine,Izmir,Turkey.
出版信息
Psychol Med. 2017 Apr;47(6):1030-1040. doi: 10.1017/S0033291716003366. Epub 2016 Dec 29.
BACKGROUND
Individuals with schizophrenia are at greater risk for metabolic syndrome (MetS) which is associated with cognitive deficits in the general population. MetS might be potentially an important contributing factor to cognitive impairment in schizophrenia.
METHOD
In the current systematic review and meta-analysis, the findings of 18 studies investigating the association between MetS (and its components) with cognitive impairment in schizophrenia are reviewed.
RESULTS
Co-morbidity of MetS (d = 0.28) and diabetes mellitus (d = 0.28) were both associated with more severe cognitive deficits in schizophrenia. There was also evidence for a significant relationship between cognitive impairment in schizophrenia and each of the components of MetS including hypertension, dyslipidemia, abdominal obesity and diabetes.
CONCLUSIONS
MetS is significantly associated with cognitive impairment in schizophrenia and can potentially contribute to functional decline observed in some patients with schizophrenia throughout the course of illness.
背景
精神分裂症患者患代谢综合征（MetS）的风险更高，而代谢综合征在普通人群中与认知缺陷相关。代谢综合征可能是精神分裂症认知障碍的一个重要促成因素。
方法
在当前的系统评价和荟萃分析中，回顾了18项研究的结果，这些研究调查了代谢综合征（及其组成部分）与精神分裂症认知障碍之间的关联。
结果
代谢综合征（d = 0.28）和糖尿病（d = 0.28）的共病均与精神分裂症更严重的认知缺陷相关。也有证据表明，精神分裂症的认知障碍与代谢综合征的各个组成部分之间存在显著关系，这些组成部分包括高血压、血脂异常、腹型肥胖和糖尿病。
结论
代谢综合征与精神分裂症的认知障碍显著相关，并可能在整个病程中导致部分精神分裂症患者出现功能衰退。
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