Liu Fengqiong, Chen Fa, Huang Jiangfeng, Yan Lingjun, Liu Fangping, Wu Junfeng, Qiu Yu, Zheng Xiaoyan, Zhang Rongzhao, Lin Lisong, He Baochang
Department of Epidemiology and Health Statistic, Fujian Provincial Key Laboratory of Environment factors and Cancer, School of Public Health, Fujian Medical University, Fujian, China.
Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fujian, China.
Oncotarget. 2017 Jan 17;8(3):4352-4359. doi: 10.18632/oncotarget.13842.
This study was performed to identify the factors affecting prognosis of oral cancer patients. 1240 pathologically confirmed oral cancer patients were included. The sociodemographic and clinical characteristics of all patients were collected. Univariate and multivariate Cox proportional hazards models were used to assess potential prognostic factors for survival. 1240 oral cancer patients were followed up for 49235.00 person months, and the 5-year overall survival rate was 64.38%. Both univariate and multivariate Cox regression analysis indicated that Body Mass Index < 18.5 kg/m2 (vs 18.5-23.9 kg/m2), age ≥ 55 years (vs < 55 years), clinical stages of II-IV (vs stage I), and poor differentiation (vs well differentiation) were associated with worse survival of oral cancer patients. While surgery (vs non-surgery) and origin of urban area (vs rural area) were protective factors. However, no significant association was found between adjuvant therapy and survival in oral cancer patients.
本研究旨在确定影响口腔癌患者预后的因素。纳入了1240例经病理确诊的口腔癌患者。收集了所有患者的社会人口学和临床特征。采用单因素和多因素Cox比例风险模型评估生存的潜在预后因素。对1240例口腔癌患者进行了49235.00人月的随访，5年总生存率为64.38%。单因素和多因素Cox回归分析均表明，体重指数<18.5kg/m²（vs 18.5-23.9kg/m²）、年龄≥55岁（vs<55岁）、临床分期为II-IV期（vs I期）以及低分化（vs高分化）与口腔癌患者较差的生存率相关。而手术（vs非手术）和城市地区来源（vs农村地区）是保护因素。然而，未发现辅助治疗与口腔癌患者生存之间存在显著关联。
