Department of Oral and Maxillofacial Surgery, College of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, China.
Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China.
Medicine (Baltimore). 2023 Oct 13;102(41):e35485. doi: 10.1097/MD.0000000000035485.
Few studies have examined oral cancer-related mortality in Guangxi. This study aimed to explore the incidence and characteristics of oral cancer and to identify the risk factors for oral cancer-related mortality. The study was conducted to provide a reference for clinical treatment and to improve the survival rate of patients with oral cancer. A total of 271 patients with oral cancer who were treated in the Stomatology Hospital of Guangxi Medical University from 2016 to 2017 were selected as the research subjects. The follow-up lasted until the middle of 2021. The survival rate and mean survival time of 271 patients were calculated by the Kaplan-Meier method. Cox proportional hazard models and stratified analysis were used to explore the related factors that affect the mortality of patients. Nomogram plots were used to visualize the relationships among multiple variables. Among 271 patients with oral cancer, the 2-year and 5-year overall survival rates were 83.8% and 68.5% respectively. The results of multivariate analysis showed that, age, pathological type, surgery and readmission were significant factors affecting survival. When the above factors were incorporated into nomogram plots and stratified analysis, the results showed that the risk of death after treatment in patients with oral cancer aged > 55 years was 1.693 times higher than that in patients aged ≤ 55 years (HR, hazard ratio [HR] = 1.795, 95% confidence intervals [CI] = 1.073, 3.004). The risk of death after surgical treatment was 0.606 times higher than that without surgical treatment (HR = 0.590, 95% CI = 0.367, 0.948). Patients who were readmitted had a 2.340-fold increased risk of death compared with patients who were not readmitted (HR = 2.340, 95% CI = 1.267,4.321). Older age, surgery, and readmission were risk factors for mortality among patients with oral cancer. The median survival time of 271 patients with oral cancer was 52.0 months. Patients under the age of 55 years old and those who choose surgical treatment tend to have a better prognosis and a longer survival. Oral cancer-related mortality is affected by age, treatment mode, readmission, and other factors. All of these factors are worthy of clinical attention for their prevention and control.
广西口腔癌相关死亡率的研究较少。本研究旨在探讨口腔癌的发病特征，并分析口腔癌相关死亡的危险因素，为临床治疗提供参考，提高口腔癌患者的生存率。选取 2016 年至 2017 年在广西医科大学附属口腔医院治疗的 271 例口腔癌患者为研究对象，随访至 2021 年中期，采用 Kaplan-Meier 法计算 271 例患者的生存率和中位生存时间，采用 Cox 比例风险模型和分层分析探讨影响患者死亡的相关因素，利用列线图可视化多个变量之间的关系。271 例口腔癌患者中，2 年和 5 年总生存率分别为 83.8%和 68.5%。多因素分析结果显示，年龄、病理类型、手术及再入院是影响生存的显著因素。将上述因素纳入列线图和分层分析，结果显示年龄>55 岁的口腔癌患者治疗后死亡风险是年龄≤55 岁患者的 1.693 倍（HR=1.795，95%CI=1.0733.004），手术治疗后死亡风险是未手术治疗患者的 0.606 倍（HR=0.590，95%CI=0.3670.948），再入院患者死亡风险是未再入院患者的 2.340 倍（HR=2.340，95%CI=1.267~4.321）。年龄较大、手术治疗及再入院是口腔癌患者死亡的危险因素。271 例口腔癌患者的中位生存时间为 52.0 个月，年龄<55 岁及选择手术治疗的患者预后较好，生存时间较长。口腔癌相关死亡受年龄、治疗方式、再入院等因素影响，这些因素均值得临床关注，以进行预防和控制。
