一名患有巨大先天性痣的患者发生恶性黑色素瘤并伴有胸腺痣。

Malignant Melanoma in Association With a Thymic Nevus in a Patient With a Giant Congenital Nevus.

作者信息

Shvartser-Beryozkin Yulia, Yakobson Alexander, Benharroch Daniel, Saute Milton, Feinmesser Meora

机构信息

*Institute of Pathology, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel; †Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; ‡Department of Oncology, Soroka Medical Center, Beer Sheva, Israel; §Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel; ¶Institute of Pathology, Soroka Medical Center, Beer Sheva, Israel; and ‖Department of Cardiothoracic Surgery, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel.

出版信息

Am J Dermatopathol. 2017 Jul;39(7):538-541. doi: 10.1097/DAD.0000000000000817.

DOI:10.1097/DAD.0000000000000817

PMID:28033154

Abstract

Nevi and melanocytic proliferations are known to appear in multiple extracutaneous sites, including lymph nodes and meninges. We report a case of an anterior mediastinal mass in a patient with a giant congenital nevus and neurofibromatosis type I. Histologically, the tumor was found to be a malignant melanoma in the thymus arising in association with a nevus that involved most of the thymic tissue. There was no sign of cutaneous melanoma on skin examination. We suggest that the tumor originated from the benign nevus in the thymus, a rare extracutaneous location for nevi and malignant melanoma.

摘要

痣和黑素细胞增生已知会出现在多个皮肤外部位，包括淋巴结和脑膜。我们报告了一例患有巨大先天性痣和I型神经纤维瘤病患者的前纵隔肿块病例。组织学检查发现，该肿瘤是胸腺中的恶性黑色素瘤，与累及大部分胸腺组织的痣相关。皮肤检查未发现皮肤黑色素瘤迹象。我们认为该肿瘤起源于胸腺中的良性痣，而胸腺是痣和恶性黑色素瘤罕见的皮肤外部位。