Li Xiaoyi, Feng Rui, Wu Hao, Zhang Lei, Zhao Lan, Dai Ning, Yu Enyan
Department of Psychiatry and Mental Health, Tongde Hospital of Zhejiang Province The Mental Health Institute of Zhejiang Province Department of Psychiatry and Mental Health, Sir Run Run SHAW Hospital, Zhejiang University School of Medicine Sir Run Run SHAW Institute of Clinical Medicine of Zhejiang University Department of Digestive System, Sir Run Run SHAW Hospital, Zhejiang University School of Medicine Department of Psychiatry, Zhejiang Provincial People's Hospital, Hangzhou, China.
Medicine (Baltimore). 2016 Dec;95(52):e5685. doi: 10.1097/MD.0000000000005685.
The emotional state, psychological characteristics, cognitive function, and the relevance among above factors in patients with functional constipation (FC) are complex. This study aimed to investigate whether FC symptoms might be related to implicit processing such as psychological characteristics and emotional somatization.Thirty-five FC patients and 24 normal volunteers were recruited to collect event-related potentials (ERP) behavior and electroencephalogram data when simple digital GoNogo visual tasks were performed. Hamilton Depression Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), Symptom Checklist, and Eysenck Personality Inventory (EPQ) were assessed before the ERP test.There was significant difference in average score, positive index, somatization, obsessive-compulsive disorder, anxiety, depression and psychoticism in HAMD-17, HAMA, Symptom Checklist, and extroversion or introversion and neuroticism in EPQ between the FC patients group and the normal control group (P < 0.05). There was a significant difference in the amplitude of ERP-P300 at site F4, F7, and FZ (P < 0.05).FC patients showed anxiety and depression. The asymmetric forebrain abnormal activities in the 2 hemispheres might initiate implicit automatic processing, such as somatization and obsessive-compulsive disorder, in order to cope with painful experience caused by anxiety and depression in patients with FC. Cognitive dysfunction of implicit processing might be involved in the abnormality of visual communication and information processing.
功能性便秘（FC）患者的情绪状态、心理特征、认知功能以及上述因素之间的相关性较为复杂。本研究旨在调查FC症状是否可能与心理特征和情绪躯体化等内隐加工有关。招募了35名FC患者和24名正常志愿者，在进行简单数字GoNogo视觉任务时收集事件相关电位（ERP）行为和脑电图数据。在ERP测试前评估汉密尔顿抑郁量表（HAMD-17）、汉密尔顿焦虑量表（HAMA）、症状清单和艾森克人格问卷（EPQ）。FC患者组与正常对照组在HAMD-17、HAMA、症状清单的平均分、阳性指数、躯体化、强迫症、焦虑、抑郁和精神病性，以及EPQ的外向性或内向性和神经质方面存在显著差异（P<0.05）。在F4、F7和FZ部位的ERP-P300波幅存在显著差异（P<0.05）。FC患者表现出焦虑和抑郁。大脑两半球不对称的前脑异常活动可能引发内隐自动加工，如躯体化和强迫症，以应对FC患者因焦虑和抑郁引起的痛苦体验。内隐加工的认知功能障碍可能与视觉交流和信息处理异常有关。
