Senaldi G, Lupoli S, Vergani D, Black C M
Department of Immunology, King's College School of Medicine and Dentistry, London, United Kingdom.
Arthritis Rheum. 1989 Oct;32(10):1262-7. doi: 10.1002/anr.1780321011.
Using newly developed techniques, we investigated the complement pathways and the extent of their activation in patients with systemic sclerosis (SSc) of both the diffuse cutaneous and limited cutaneous types. Plasma levels of the fragments C3d, C4d, and Ba were measured in patients with SSc and in matched control subjects. All fragments and ratios were higher in SSc patients than in controls (P less than 0.05), demonstrating that complement activation occurs in SSc. Levels of C3d, C3d:C3, Ba, and Ba:factor B were higher in patients with diffuse cutaneous SSc patients than in controls (P less than 0.01). C3d, C3d:C3, C4d, and C4d:C4 levels were also higher in patients with limited cutaneous SSc than in controls (P less than 0.05). These results show that complement activation occurs in SSc patients and that it reflects clinical severity. Complement activation may therefore have a pathogenetic role in SSc, and its measurement may prove useful in monitoring the disease.
我们运用新开发的技术，对弥漫性皮肤型和局限性皮肤型系统性硬化症（SSc）患者的补体途径及其激活程度进行了研究。测定了SSc患者和匹配的对照受试者血浆中C3d、C4d和Ba片段的水平。SSc患者的所有片段及比值均高于对照组（P<0.05），表明补体激活在SSc中发生。弥漫性皮肤型SSc患者的C3d、C3d:C3、Ba和Ba:因子B水平高于对照组（P<0.01）。局限性皮肤型SSc患者的C3d、C3d:C3、C4d和C4d:C4水平也高于对照组（P<0.05）。这些结果表明补体激活在SSc患者中发生，且反映了临床严重程度。因此，补体激活可能在SSc中具有致病作用，其检测可能对监测疾病有用。
