Soler J T, Folsom A R, Kaye S A, Prineas R J
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55455.
Atherosclerosis. 1989 Sep;79(1):21-7. doi: 10.1016/0021-9150(89)90029-4.
The associations of abdominal adiposity, fasting serum levels of insulin, and sex hormones with blood lipids, lipoproteins, and apolipoproteins A-I and B were studied cross-sectionally in 75 healthy, postmenopausal white women. In univariate analyses, abdominal adiposity (increased waist-to-hip girth ratio) and fasting insulin concentrations were negatively and significantly associated (P less than 0.05) with plasma high density lipoprotein cholesterol (r = -0.47 and -0.38, respectively) and apolipoprotein A-I (r = -0.37 and -0.36), and positively associated with log triglycerides (r = 0.54 and 0.33) and apolipoprotein B (r = 0.43 and 0.22). Sex hormone binding globulin was positively and significantly associated with high density lipoprotein cholesterol (r = 0.32) and negatively associated with log triglyceride (r = -0.45) and apolipoprotein B (r = -0.36). Estrone was positively and significantly associated with high density lipoprotein cholesterol (r = 0.27), apolipoprotein A-I (r = 0.23) and negatively associated with low density lipoprotein cholesterol (r = -0.24) and apolipoprotein B (r = -0.25). Total estradiol, free estradiol, free testosterone, and total testosterone were more weakly associated with the lipid measures. In multivariate analyses, abdominal adiposity remained significantly associated with high density lipoprotein cholesterol, log triglycerides, apolipoproteins A-I and B after adjustment for sex hormone binding globulin, estrone, and insulin concentrations. Insulin remained associated only with apolipoprotein A-I after adjustment for abdominal adiposity, estrone, and sex hormone binding globulin. Sex hormone binding globulin remained marginally associated with log triglyceride (P = 0.07) after adjustment for the remaining three factors. Estrone remained significantly associated with high density lipoprotein cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)
对75名健康的绝经后白人女性进行了横断面研究，以探讨腹部肥胖、空腹血清胰岛素水平和性激素与血脂、脂蛋白以及载脂蛋白A-I和B之间的关联。在单变量分析中，腹部肥胖（腰臀围比增加）和空腹胰岛素浓度与血浆高密度脂蛋白胆固醇（分别为r = -0.47和-0.38）及载脂蛋白A-I（r = -0.37和-0.36）呈负相关且具有显著性（P小于0.05），与对数甘油三酯（r = 0.54和0.33）及载脂蛋白B（r = 0.43和0.22）呈正相关。性激素结合球蛋白与高密度脂蛋白胆固醇呈正相关且具有显著性（r = 0.32），与对数甘油三酯（r = -0.45）和载脂蛋白B（r = -0.36）呈负相关。雌酮与高密度脂蛋白胆固醇呈正相关且具有显著性（r = 0.27）、与载脂蛋白A-I呈正相关（r = 0.23），与低密度脂蛋白胆固醇（r = -0.24）和载脂蛋白B（r = - .25）呈负相关。总雌二醇、游离雌二醇、游离睾酮和总睾酮与血脂指标的关联较弱。在多变量分析中，在调整了性激素结合球蛋白、雌酮和胰岛素浓度后，腹部肥胖仍与高密度脂蛋白胆固醇、对数甘油三酯、载脂蛋白A-I和B显著相关。在调整了腹部肥胖、雌酮和性激素结合球蛋白后，胰岛素仅与载脂蛋白A-I相关。在调整了其余三个因素后，性激素结合球蛋白与对数甘油三酯仍存在边缘关联（P = 0.07）。雌酮仍与高密度脂蛋白胆固醇显著相关。（摘要截短于250字）
