Ding Rongcai, Li Yingxue, Chang Yaoyao, Liu Yue, Yu Jie, Lv Yanna, Hu Jinxing
School of Pharmacy, Weifang Medical University, Weifang, China.
Front Chem. 2021 Apr 30;9:672051. doi: 10.3389/fchem.2021.672051. eCollection 2021.
A novel and efficient - vinylation reaction with quinoxalin-2(1)-one as the substrate, in the presence of alkenes, under metal-free conditions, is reported herein. The reaction leads to the formation of new carbon-carbon bonds that exhibit moderate to good reactivities. The vinylation of quinoxalin-2(1)-ones, in the presence of alkenes, is an attractive process that can be potentially utilized to produce biologically active 3-vinylated quinoxalin-2(1)-ones.
本文报道了一种以喹喔啉-2(1)-酮为底物，在无金属条件下与烯烃发生的新型高效的乙烯基化反应。该反应导致形成具有中等至良好反应活性的新碳-碳键。在烯烃存在下喹喔啉-2(1)-酮的乙烯基化是一个有吸引力的过程，可潜在地用于生产具有生物活性的3-乙烯基喹喔啉-2(1)-酮。
