Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China.
State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, PR China.
Sci Total Environ. 2017 Feb 15;580:572-581. doi: 10.1016/j.scitotenv.2016.11.214. Epub 2016 Dec 27.
Black carbon (BC) is a key component of atmospheric particles and has a significant effect on human health. BC can provide reactive sites and surfaces thus absorb quinones which were primarily generated from fossil fuel combustion and/or atmospheric photochemical conversions of PAHs. Oxidation could change the characteristics of BC and increase its toxicity. The comparison of lung damage in mice exposed to BC and 1,4-NQ-coated BC (1,4NQ-BC) particles is investigated in this study. Mice which were intratracheally instilled with particles have a higher expression of IL-1β, IL-6 and IL-33 in bronchoalveolar lavage fluid (BALF). Also, the IL-6, IL-33 mRNA expression in the lung tissue of mice instilled with 1,4NQ-BC were higher than that of mice instilled with BC. The pathology results showed that the lung tissue of mice instilled with 1,4NQ-BC particles have much more inflammatory cells infiltration than that of mice treated with BC. It is believed that the MAPK and PI3K-AKT pathway might be involved in the 1,4NQ-BC particles caused lung damage. Results indicated that 1,4NQ-BC particles in the atmosphere may cause more damage to health.
黑碳（BC）是大气颗粒物的重要组成部分，对人体健康有重大影响。BC 可以提供反应性位点和表面，从而吸收主要来源于化石燃料燃烧和/或多环芳烃大气光化学反应的醌。氧化可以改变 BC 的特性并增加其毒性。本研究比较了暴露于 BC 和 1,4-NQ 涂层 BC（1,4NQ-BC）颗粒的小鼠的肺部损伤。通过气管内滴注颗粒的小鼠在支气管肺泡灌洗液（BALF）中 IL-1β、IL-6 和 IL-33 的表达更高。此外，1,4NQ-BC 滴注小鼠的肺组织中 IL-6、IL-33 mRNA 表达高于 BC 滴注小鼠。病理学结果表明，1,4NQ-BC 颗粒滴注小鼠的肺组织中炎症细胞浸润比 BC 处理组小鼠更多。据信，MAPK 和 PI3K-AKT 通路可能参与了 1,4NQ-BC 颗粒引起的肺损伤。结果表明，大气中的 1,4NQ-BC 颗粒可能对健康造成更大的损害。
