Liu Xinlei, Wang Yuejiao, Shen Zelin, Wu Xuan, Shi Yu, Wang Fang
College of Environmental Science and Engineering, Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Tianjin Key Laboratory of Environmental Remediation and Pollution Control, Nankai University, Tianjin, 300350, China.
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, China.
MethodsX. 2019 Mar 18;6:558-566. doi: 10.1016/j.mex.2019.03.009. eCollection 2019.
This study was conducted to evaluate the inhalation carcinogenic risk of PAHs in biochar fine particles using total concentration-based assessment approach and bioaccessibility-based assessment approach. Only limit PAHs in particles can be released in simulated lung fluids, leading to a low bioaccessibility (only ranging from 0.34% to 1.48% for biochar fine particles and from 3.21% to 44.2% for PM), which would significantly affect health risk assessment. Therefore, bioaccessibility should always be favored over more traditional evaluations based on total concentration, while evaluating inhalation health risks of biochar-bound PAHs. To prove the broad applicability of bioaccessibility-based assessment approaches, we also compared health risk of actual atmospheric particles (PM collected from Nanjing, China) using total concentration-based approaches and bioaccessibility-based approaches. •Proposed bioaccessibility-based approaches for assessing biochar risk are more accurate than traditional total concentration-based approaches;•Proposed bioaccessibility-based approaches can be applied to health risk assessment of actual air particles;•A more practical method was proposed to evaluate the bioaccessibility of PAHs in biochar fine particles or other specific component of atmospheric particle matters: using wet sieving method to prepare fine particles, using volatile organic solvent-drying method to load C-PAHs on fine particles, and using desorption experiments to determine bioaccessibility of PAHs.
本研究旨在使用基于总浓度的评估方法和基于生物可及性的评估方法，评估生物炭细颗粒中多环芳烃的吸入致癌风险。只有颗粒中的限量多环芳烃能够在模拟肺液中释放，导致生物可及性较低（生物炭细颗粒仅在0.34%至1.48%之间，颗粒物在3.21%至44.2%之间），这将显著影响健康风险评估。因此，在评估生物炭结合多环芳烃的吸入健康风险时，应始终优先考虑生物可及性，而不是基于总浓度的更传统评估。为了证明基于生物可及性的评估方法具有广泛的适用性，我们还使用基于总浓度的方法和基于生物可及性的方法，比较了实际大气颗粒物（从中国南京采集的PM）的健康风险。• 提出的基于生物可及性的生物炭风险评估方法比传统的基于总浓度的方法更准确；• 提出的基于生物可及性的方法可应用于实际空气颗粒物的健康风险评估；• 提出了一种更实用的方法来评估生物炭细颗粒或大气颗粒物其他特定成分中多环芳烃的生物可及性：使用湿筛法制备细颗粒，使用挥发性有机溶剂干燥法将碳多环芳烃负载在细颗粒上，并使用解吸实验确定多环芳烃的生物可及性。
