在有主观认知衰退的社区居住个体中，睡眠改变而内侧颞叶或大脑皮质无变化。
Sleep changes without medial temporal lobe or brain cortical changes in community-dwelling individuals with subjective cognitive decline.
作者信息
Lauriola Mariella, Esposito Roberto, Delli Pizzi Stefano, de Zambotti Massimiliano, Londrillo Francesco, Kramer Joel H, Rabinovici Gil D, Tartaro Armando
机构信息
Department of Neuroscience, Imaging and Clinical Science, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; Institute for Advanced Biomedical Technologies, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Department of Neuroscience, Imaging and Clinical Science, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; Institute for Advanced Biomedical Technologies, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
出版信息
Alzheimers Dement. 2017 Jul;13(7):783-791. doi: 10.1016/j.jalz.2016.11.006. Epub 2016 Dec 27.
INTRODUCTION
Subjective cognitive decline (SCD) is a risk factor for mild cognitive impairment (MCI) and Alzheimer's disease (AD). Although sleep has been shown to be altered in MCI and AD, little is known about sleep in SCD.
METHODS
Seventy cognitively normal community-dwelling participants were classified as SCD (32) or controls (38) using the Subjective Cognitive Decline Questionnaire. Sleep was assessed using actigraphy and diaries. FreeSurfer was used for performing medial temporal lobes (MTLs) and brain cortical parcellation of 3T magnetic resonance images. Multiple regression models were used to assess the presence of sleep, MTL, or regional cortical differences between groups.
RESULTS
Objective sleep was disrupted in SCD participants, which showed increased nighttime wakefulness and reduced sleep efficiency. No group differences emerged in subjective sleep or magnetic resonance imaging outcomes.
DISCUSSION
Objective sleep resulted disrupted in community-dwelling SCD, without any subjective sleep or cortical change. Sleep assessment/intervention in SCD might help prevent/delay AD onset.
引言
主观认知衰退（SCD）是轻度认知障碍（MCI）和阿尔茨海默病（AD）的一个风险因素。尽管已有研究表明MCI和AD患者的睡眠存在改变，但对于SCD患者的睡眠情况却知之甚少。
方法
使用主观认知衰退问卷将70名认知正常的社区居住参与者分为SCD组（32人）或对照组（38人）。通过活动记录仪和日记对睡眠进行评估。利用FreeSurfer软件对3T磁共振图像进行内侧颞叶（MTL）和脑皮质分区。采用多元回归模型评估两组之间睡眠、MTL或区域皮质的差异。
结果
SCD参与者的客观睡眠受到干扰，表现为夜间觉醒增加和睡眠效率降低。主观睡眠或磁共振成像结果在两组之间未出现差异。
讨论
社区居住的SCD患者的客观睡眠受到干扰，且无任何主观睡眠或皮质变化。对SCD进行睡眠评估/干预可能有助于预防/延缓AD的发病。
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