Bruno Aldo, Napolitano Marisanta, Califano Luigi, Attanasio Giuseppe, Giugliano Vincenzo, Cavazzuti Pier Paolo, Viccaro Marika, Masci Eleonora, Mastrangelo Diego, Salafia Francesca, Mazzone Salvatore, Bernardo Benedetto, Cagnoni Laura, Filipo Roberto, De Vincentis Marco, Greco Antonio
Vascular Surgery Division, Gepos Clinic Telese Terme, Benevento, Italy.
Hematology Unit, Palermo University, Palermo, Italy.
J Vasc Interv Radiol. 2017 Mar;28(3):388-391. doi: 10.1016/j.jvir.2016.10.019. Epub 2016 Dec 27.
To evaluate relationship between Meniere disease (MD) and chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound, magnetic resonance (MR) imaging, and venography and to evaluate the effectiveness of angioplasty of the internal jugular vein (IJV) and azygos vein (AV) in reducing symptoms of MD.
Patients with a confirmed diagnosis of MD unresponsive to standard treatment underwent duplex ultrasound and MR imaging to diagnose CCSVI. Healthy volunteers were also studied to evaluate CCSVI in asymptomatic subjects. Patients with CCSVI and MD underwent venography and percutaneous transluminal angioplasty (PTA) of IJV and AV.
There were 182 patients with no clinical benefit from standard treatments evaluated. CCSVI was diagnosed in 175 (87.5%) patients with MD. Venography was performed in 69 patients to confirm the diagnosis of CCSVI. In 80% of these patients, PTA of the IJV and/or AV was effective for treating signs and symptoms of MD. In the healthy cohort, CCSVI was observed in only 12% of subjects.
These results suggest a possible etiologic relationship between CCSVI and MD that warrants further investigation.
利用超声、磁共振成像（MR）及静脉造影评估梅尼埃病（MD）与慢性脑脊髓静脉功能不全（CCSVI）之间的关系，并评估颈内静脉（IJV）和奇静脉（AV）血管成形术在减轻MD症状方面的有效性。
确诊为MD且对标准治疗无反应的患者接受双功超声和MR成像以诊断CCSVI。还对健康志愿者进行研究以评估无症状受试者中的CCSVI情况。患有CCSVI和MD的患者接受静脉造影以及IJV和AV的经皮腔内血管成形术（PTA）。
共评估了182例从标准治疗中未获得临床益处的患者。175例（87.5%）MD患者被诊断为CCSVI。对69例患者进行了静脉造影以确诊CCSVI。在这些患者中，80%的IJV和/或AV的PTA对治疗MD的体征和症状有效。在健康队列中，仅12%的受试者观察到CCSVI。
这些结果提示CCSVI与MD之间可能存在病因学关系，值得进一步研究。
