梅尼埃病中的慢性脑脊髓静脉功能不全。
Chronic cerebrospinal venous insufficiency in Ménière disease.
作者信息
Di Berardino Federica, Alpini Dario Carlo, Bavera Pietro Maria, Cecconi Piero, Farabola Mario, Mattei Valentina, Ambrosetti Umberto, Cesarani Antonio
机构信息
Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy Audiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
ENT-Otoneurology Service, Scientific Institute S. Maria Nascente, Don C. Gnocchi Foundation, Milan, Italy.
出版信息
Phlebology. 2015 May;30(4):274-9. doi: 10.1177/0268355514526871. Epub 2014 Mar 4.
OBJECTIVES
The aim of this study was to focus on patients suffering from cochleo-vestibular disorder with and without Ménière disease (MD) in order to verify whether chronic cerebrospinal drainage abnormalities could play a role in the etiopathogenesis of endolymphatic hydrops.
METHODS
Fifty-two volunteers were enrolled and subdivided into two groups: 24 definite MD and 28 not-MD. Both magnetic resonance venography imaging with contrast-enhanced imaging of the venous cerebrospinal system (MRV) and venous echo-color Doppler (ECD) were performed.
RESULTS
MRV showed abnormalities in 83% of MD and 57% of not-MD subjects (p < 0.001). Asymmetrical cervical venous flow, assessed by MRV, was confirmed by ECD in 62.5% of MD but in only 21.5% of not-MD subjects (p<0.001).
CONCLUSION
Chronic cerebrospinal venous insufficiency might be the anatomical background, which provides a predisposing factor for the development of endolymphatic hydrops in MD patients.
目的
本研究旨在聚焦患有和未患有梅尼埃病（MD）的耳蜗 - 前庭疾病患者，以验证慢性脑脊液引流异常是否可能在内淋巴积水的发病机制中起作用。
方法
招募了52名志愿者并将其分为两组：24名确诊为MD患者和28名非MD患者。对两组均进行了静脉注射造影剂的静脉脑脊液系统磁共振静脉血管造影成像（MRV）以及静脉彩色多普勒超声（ECD）检查。
结果
MRV显示，83%的MD患者和57%的非MD患者存在异常（p<0.001）。通过MRV评估的不对称颈静脉血流，经ECD证实，在62.5%的MD患者中存在，但在仅21.5%的非MD患者中存在（p<0.001）。
结论
慢性脑脊液静脉功能不全可能是解剖学背景，它为MD患者内淋巴积水的发展提供了一个易感因素。
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