Barquissau Valentin, Ghandour Rayane A, Ailhaud Gérard, Klingenspor Martin, Langin Dominique, Amri Ez-Zoubir, Pisani Didier F
Inserm, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 31432, France; University of Toulouse, UMR1048, Paul Sabatier University, Toulouse, 31432, France.
Université Côte d'Azur, CNRS, Inserm, iBV, France.
Biochimie. 2017 May;136:3-11. doi: 10.1016/j.biochi.2016.12.012. Epub 2016 Dec 27.
Oxylipins are bioactive metabolites derived from the oxygenation of ω3 and ω6 polyunsaturated fatty acids, triggered essentially by cyclooxygenase and lipoxygenase activities. Oxylipins are involved in the development and function of adipose tissue and their productions are strictly related to diet quality and quantity. Oxylipins signal via cell surface membrane (G Protein-coupled receptors) and nuclear receptors (peroxisome proliferator-activated receptors), two pathways playing a pivotal role in adipocyte biology. In this review, we made an attempt to cover the available knowledge about synthesis and molecular function of oxylipins known to modulate adipogenesis, adipocyte function and phenotype conversion, with a focus on their interaction with peroxisome proliferator-activated nuclear receptor family.
氧化脂质是由ω3和ω6多不饱和脂肪酸氧化产生的生物活性代谢产物，主要由环氧化酶和脂氧化酶的活性引发。氧化脂质参与脂肪组织的发育和功能，其产生与饮食的质量和数量密切相关。氧化脂质通过细胞表面膜（G蛋白偶联受体）和核受体（过氧化物酶体增殖物激活受体）发出信号，这两条途径在脂肪细胞生物学中起关键作用。在这篇综述中，我们试图涵盖已知调节脂肪生成、脂肪细胞功能和表型转化的氧化脂质的合成和分子功能的现有知识，重点关注它们与过氧化物酶体增殖物激活核受体家族的相互作用。
