N'krumah Raymond T A S, Koné Brama, Cissé Guéladio, Tanner Marcel, Utzinger Jürg, Pluschke Gerd, Tiembré Issaka
Département Recherche et Développement, Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, 01 BP 1303, Abidjan 01, Côte d'Ivoire; Unité de Formation et de Recherche des Sciences Médicales, Université Félix Houphouët-Boigny, 01 BP V 34, Abidjan 01, Côte d'Ivoire.
Département Recherche et Développement, Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, 01 BP 1303, Abidjan 01, Côte d'Ivoire; Institut de Gestion Agropastorale, Université Péléforo Gon Coulibaly, BP 1328, Korhogo, Côte d'Ivoire.
Acta Trop. 2017 Nov;175:138-144. doi: 10.1016/j.actatropica.2016.12.023. Epub 2016 Dec 27.
Buruli ulcer (BU) is a cutaneous infectious disease caused by Mycobacterium ulcerans. It is the third most common mycobacterial disease in the world in the immunocompetent patient and second in Côte d'Ivoire after tuberculosis. This study aimed to assess the characteristics and epidemiological profile of BU in the district of Tiassalé, an important focus of the disease in south Côte d'Ivoire, in order to better direct actions for prevention and control. Retrospective clinical data of BU cases in the period 2005-2010 from all 19 district health centres were collected and linked with geographical and environmental survey data. A total of 1145 cases of BU were recorded between 2005 and 2010 in the district of Tiassalé. Children under the age of 15 years were the most affected (53.0%) with a higher prevalence among males compared to females (54.7% versus 45.3%). Among individuals aged 15-49 years, females had a higher prevalence than males (54.2% versus 45.8%). The villages of Ahondo, Léléblé and Taabo, located in close proximity to the man-made Lake Taabo that was constructed in the late 1970s by damming the Bandama River, and the village of Sokrogbo located downstream of the dam, showed the highest BU rates in the sub-prefecture of Taabo. In the sub-prefecture of Tiassalé, the villages of Affikro, Morokro and N'Zianouan, located near N'Zi River, a tributary of the Bandama River, were the most affected. The distribution of BU is associated with environmental patterns (i.e. distance between village and Lake Taabo or Bandama River and its tributary N'Zi River). Awareness campaigns, coupled with early diagnosis and improved clinical management of BU, have been implemented in the district of Tiassalé and the incidence of BU has declined.
布氏杆菌溃疡（BU）是由溃疡分枝杆菌引起的一种皮肤传染病。在免疫功能正常的患者中，它是世界上第三常见的分枝杆菌病，在科特迪瓦，仅次于结核病，位居第二。本研究旨在评估布氏杆菌溃疡在阿比让大区的特点和流行病学特征，阿比让大区是科特迪瓦南部该疾病的一个重要疫源地，以便更好地指导预防和控制行动。收集了2005年至2010年期间所有19个区卫生中心的布氏杆菌溃疡病例的回顾性临床数据，并将其与地理和环境调查数据相联系。2005年至2010年期间，阿比让大区共记录了1145例布氏杆菌溃疡病例。15岁以下儿童受影响最大（53.0%），男性患病率高于女性（54.7%对45.3%）。在15至49岁的人群中，女性患病率高于男性（54.2%对45.8%）。位于20世纪70年代末通过筑坝班达马河形成的人工湖塔博湖附近的阿洪多、莱莱布莱和塔博村，以及位于大坝下游的索克罗博村，在塔博县的布氏杆菌溃疡发病率最高。在阿比让县，位于班达马河支流恩齐河附近的阿菲克罗、莫罗克罗和恩齐亚努安村受影响最大。布氏杆菌溃疡的分布与环境模式有关（即村庄与塔博湖或班达马河及其支流恩齐河之间的距离）。阿比让大区已开展了宣传活动，并加强了布氏杆菌溃疡的早期诊断和临床管理，布氏杆菌溃疡的发病率有所下降。
