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Plerixafor and G-CSF combination mobilizes hematopoietic stem and progenitors cells with a distinct transcriptional profile and a reduced homing capacity compared to plerixafor alone.

作者信息

Lidonnici Maria Rosa, Aprile Annamaria, Frittoli Marta Claudia, Mandelli Giacomo, Paleari Ylenia, Spinelli Antonello, Gentner Bernhard, Zambelli Matilde, Parisi Cristina, Bellio Laura, Cassinerio Elena, Zanaboni Laura, Cappellini Maria Domenica, Ciceri Fabio, Marktel Sarah, Ferrari Giuliana

机构信息

San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Vita-Salute San Raffaele University, Milan, Italy.

出版信息

Haematologica. 2017 Apr;102(4):e120-e124. doi: 10.3324/haematol.2016.154740. Epub 2016 Dec 29.

DOI:10.3324/haematol.2016.154740
PMID:28034992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5395121/
Abstract
摘要

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Plerixafor and G-CSF combination mobilizes hematopoietic stem and progenitors cells with a distinct transcriptional profile and a reduced homing capacity compared to plerixafor alone.与单独使用普乐沙福相比，普乐沙福与粒细胞集落刺激因子（G-CSF）联合使用可动员具有独特转录谱和归巢能力降低的造血干细胞和祖细胞。
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2
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本文引用的文献

1
Mild Heat Treatment Primes Human CD34(+) Cord Blood Cells for Migration Toward SDF-1α and Enhances Engraftment in an NSG Mouse Model.轻度热处理使人类CD34(+)脐血细胞对SDF-1α产生趋化性并增强在NSG小鼠模型中的植入。
Stem Cells. 2015 Jun;33(6):1975-84. doi: 10.1002/stem.1988.
2
Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells.转录组分析鉴定造血干细胞和祖细胞的调控因子。
Stem Cell Reports. 2013 Aug 15;1(3):266-80. doi: 10.1016/j.stemcr.2013.07.004. eCollection 2013.
3
Hematopoietic stem cell mobilization for gene therapy: superior mobilization by the combination of granulocyte-colony stimulating factor plus plerixafor in patients with β-thalassemia major.造血干细胞动员用于基因治疗：在重型β地中海贫血患者中，粒细胞集落刺激因子联合普乐沙福可实现更好的动员效果。
Hum Gene Ther. 2013 Oct;24(10):852-60. doi: 10.1089/hum.2013.163.
4
Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4.使用 CXCR4 和 VLA-4 的抑制剂动员造血干细胞和祖细胞。
Leukemia. 2012 Jan;26(1):34-53. doi: 10.1038/leu.2011.197. Epub 2011 Sep 2.
5
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.分离能够长期多谱系植入的单个人类造血干细胞。
Science. 2011 Jul 8;333(6039):218-21. doi: 10.1126/science.1201219.
6
Twenty-five years of peripheral blood stem cell transplantation.外周血干细胞移植 25 年。
Blood. 2011 Jun 16;117(24):6411-6. doi: 10.1182/blood-2010-12-322214. Epub 2011 Apr 1.
7
Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signatures.普乐沙福（AMD3100）和粒细胞集落刺激因子（G-CSF）基于整体基因和微小RNA表达特征动员不同的CD34+细胞群体。
Blood. 2009 Sep 17;114(12):2530-41. doi: 10.1182/blood-2009-04-214403. Epub 2009 Jul 14.
8
Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma.普乐沙福与粒细胞集落刺激因子对比安慰剂与粒细胞集落刺激因子用于动员多发性骨髓瘤患者造血干细胞以进行自体干细胞移植
Blood. 2009 Jun 4;113(23):5720-6. doi: 10.1182/blood-2008-08-174946. Epub 2009 Apr 10.
9
Human progenitor cells rapidly mobilized by AMD3100 repopulate NOD/SCID mice with increased frequency in comparison to cells from the same donor mobilized by granulocyte colony stimulating factor.与粒细胞集落刺激因子动员的来自同一供体的细胞相比，AMD3100快速动员的人祖细胞能以更高的频率重新填充NOD/SCID小鼠。
Biol Blood Marrow Transplant. 2007 Apr;13(4):398-411. doi: 10.1016/j.bbmt.2006.12.445.
10
The CXCR4 antagonist AMD3100 releases a subset of G-CSF-primed peripheral blood progenitor cells with specific gene expression characteristics.
Exp Hematol. 2006 Aug;34(8):1052-9. doi: 10.1016/j.exphem.2006.06.003.