囊性纤维化患者真菌感染的发病机制
Pathogenesis of Fungal Infections in Cystic Fibrosis.
作者信息
Williams Craig, Ranjendran Ranjith, Ramage Gordon
机构信息
Institute of Healthcare Policy and Practice, University of West of Scotland, Paisley, UK.
Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
出版信息
Curr Fungal Infect Rep. 2016;10(4):163-169. doi: 10.1007/s12281-016-0268-z. Epub 2016 Dec 7.
Abstract
For a long time, the microbiology of cystic fibrosis has been focussed on and associated Gram-negative pathogens. An increasing body of evidence has been compiled demonstrating an important role for moulds and yeasts within this complex patient group. Whether or not fungi are active participants, spectators or transient passersby remain to be elucidated. However, functionally, they do appear to play a contributory role in pathogenesis, albeit we do not know if this is a direct or indirect effect. The following review examines some of the key evidence for the role of fungi in CF pathogenesis.
摘要
长期以来，囊性纤维化的微生物学研究一直聚焦于革兰氏阴性病原体。越来越多的证据表明，霉菌和酵母菌在这一复杂患者群体中发挥着重要作用。真菌究竟是活跃参与者、旁观者还是短暂过客，仍有待阐明。然而，从功能上看，它们似乎在发病机制中起到了一定作用，尽管我们尚不清楚这是直接还是间接影响。以下综述探讨了真菌在囊性纤维化发病机制中作用的一些关键证据。
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Chronic Aspergillus fumigatus colonization of the pediatric cystic fibrosis airway is common and may be associated with a more rapid decline in lung function.小儿囊性纤维化气道慢性烟曲霉定植很常见，且可能与肺功能下降更快有关。
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