Tabur S, Korkmaz H, Baysal E, Hatipoglu E, Aytac I, Akarsu E
Division of Endocrinology and Diabetes, Department of Internal Medicine, Gaziantep University Medical Faculty, Gaziantep, Turkey.
Division of Endocrinology and Diabetes, Department of Internal Medicine, Endocrinology and Metabolic Disease, Edirne State Hospital, 22030, Edirne, Turkey.
J Endocrinol Invest. 2017 Jun;40(6):621-626. doi: 10.1007/s40618-016-0602-x. Epub 2016 Dec 29.
The aim of this study is to determine the changes involving auditory system in cases with acromegaly.
Otological examinations of 41 cases with acromegaly (uncontrolled n = 22, controlled n = 19) were compared with those of age and gender-matched 24 healthy subjects. Whereas the cases with acromegaly underwent examination with pure tone audiometry (PTA), speech audiometry for speech discrimination (SD), tympanometry, stapedius reflex evaluation and otoacoustic emission tests, the control group did only have otological examination and PTA. Additionally, previously performed paranasal sinus-computed tomography of all cases with acromegaly and control subjects were obtained to measure the length of internal acoustic canal (IAC).
PTA values were higher (p < 0.001 for right ears and p = 0.001 for left ears), and SD scores were (p = 0.002 for right ears and p = 0.002 for left ears) lower in acromegalic patients. IAC width in acromegaly group was narrower compared to that in control group (p = 0.03 for right ears and p = 0.02 for left ears). When only cases with acromegaly were taken into consideration, PTA values in left ears had positive correlation with growth hormone and insulin-like growth factor-1 levels (r = 0.4, p = 0.02 and r = 0.3, p = 0.03). Of all cases with acromegaly 13 (32%) had hearing loss in at least one ear, 7 (54%) had sensorineural type and 6 (46%) had conductive type hearing loss.
Acromegaly may cause certain changes in the auditory system in cases with acromegaly. The changes in the auditory system may be multifactorial causing both conductive and sensorioneural defects.
本研究旨在确定肢端肥大症患者听觉系统的变化情况。
将41例肢端肥大症患者（未控制组n = 22，控制组n = 19）的耳科检查结果与24名年龄和性别匹配的健康受试者的检查结果进行比较。肢端肥大症患者接受了纯音听力测定（PTA）、言语辨别言语听力测定（SD）、鼓室图、镫骨肌反射评估和耳声发射测试，而对照组仅进行了耳科检查和PTA。此外，获取了所有肢端肥大症患者和对照受试者之前进行的鼻窦计算机断层扫描，以测量内耳道（IAC）的长度。
肢端肥大症患者的PTA值较高（右耳p < 0.001，左耳p = 0.001），SD得分较低（右耳p = 0.002，左耳p = 0.002）。肢端肥大症组的IAC宽度比对照组窄（右耳p = 0.03，左耳p = 0.02）。仅考虑肢端肥大症患者时，左耳的PTA值与生长激素和胰岛素样生长因子-1水平呈正相关（r = 0.4，p = 0.02；r = 0.3，p = 0.03）。在所有肢端肥大症患者中，13例（32%）至少有一只耳朵听力损失，7例（54%）为感音神经性听力损失，6例（46%）为传导性听力损失。
肢端肥大症可能导致听觉系统发生某些变化。听觉系统的变化可能是多因素的，会导致传导性和感音神经性缺陷。
