Kolasinski James, Makin Tamar R, Logan John P, Jbabdi Saad, Clare Stuart, Stagg Charlotte J, Johansen-Berg Heidi
Oxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
University College, Oxford, United Kingdom.
Elife. 2016 Dec 30;5:e17280. doi: 10.7554/eLife.17280.
Experience-dependent reorganisation of functional maps in the cerebral cortex is well described in the primary sensory cortices. However, there is relatively little evidence for such cortical reorganisation over the short-term. Using human somatosensory cortex as a model, we investigated the effects of a 24 hr gluing manipulation in which the right index and right middle fingers (digits 2 and 3) were adjoined with surgical glue. Somatotopic representations, assessed with two 7 tesla fMRI protocols, revealed rapid off-target reorganisation in the non-manipulated fingers following gluing, with the representation of the ring finger (digit 4) shifted towards the little finger (digit 5) and away from the middle finger (digit 3). These shifts were also evident in two behavioural tasks conducted in an independent cohort, showing reduced sensitivity for discriminating the temporal order of stimuli to the ring and little fingers, and increased substitution errors across this pair on a speeded reaction time task.
在初级感觉皮层中，经验依赖性的大脑皮层功能图谱重组已有充分描述。然而，短期内这种皮层重组的证据相对较少。我们以人类躯体感觉皮层为模型，研究了一种持续24小时的粘贴操作的影响，该操作使用手术胶水将右手食指和右手中指（第2和第3指）连接在一起。通过两种7特斯拉功能磁共振成像方案评估的躯体感觉表征显示，粘贴后未受操作的手指出现了快速的非目标重组，无名指（第4指）的表征向小指（第5指）移动，远离中指（第3指）。在另一独立队列中进行的两项行为任务中，这些变化也很明显，表现为辨别无名指和小指刺激时间顺序的敏感性降低，以及在快速反应时间任务中这一对手指间的替代错误增加。
