Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
J Clin Periodontol. 2017 Mar;44(3):266-274. doi: 10.1111/jcpe.12691. Epub 2017 Feb 4.
The aim of this study was to investigate periodontitis as a risk factor for incident type 2 diabetes mellitus (T2DM) in a group of men aged 58-72 years.
One thousand three hundred and thirty-one dentate, diabetes-free men in Northern Ireland underwent a detailed periodontal examination during 2001-2003. Follow-up was by bi-annual questionnaire and for those reporting diabetes their general medical practitioner was contacted to validate diabetes type, treatment and diagnosis date. Cox's proportional hazard models were used to estimate the effect of periodontitis on incident diabetes. Multivariable analysis included adjustment for various known confounders.
The mean age of the men was 63.7 (SD 3.0) years. There were 80 cases (6.0%) of incident T2DM. Follow-up was for a median period of 7.8 years (IQR 6.7-8.3). After adjusting for confounding variables, the hazard ratio (HR) for incident T2DM in men with moderate/severe periodontitis versus those with no/mild periodontitis was 1.69 (95% CI 1.06-2.69), p = 0.03.
There was evidence in this homogenous group of dentate men, that those with moderate to severe periodontitis had a significantly increased risk of incident T2DM.
本研究旨在调查牙周炎是否是 58-72 岁男性发生 2 型糖尿病（T2DM）的危险因素。
北爱尔兰的 1331 名有牙、无糖尿病的男性在 2001-2003 年期间接受了详细的牙周检查。随访通过两年一次的问卷调查进行，对于报告患有糖尿病的人，联系他们的全科医生以验证糖尿病类型、治疗和诊断日期。Cox 比例风险模型用于估计牙周炎对新发糖尿病的影响。多变量分析包括对各种已知混杂因素的调整。
男性的平均年龄为 63.7（SD 3.0）岁。有 80 例（6.0%）新发 T2DM。中位随访期为 7.8 年（IQR 6.7-8.3）。在调整混杂变量后，中重度牙周炎男性发生新发 T2DM 的风险比（HR）为无/轻度牙周炎男性的 1.69（95%CI 1.06-2.69），p=0.03。
在这群同质的有牙男性中，有中度至重度牙周炎的人发生新发 T2DM 的风险显著增加。
