Department of Biomedical Sciences, Seoul National University Graduate School, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, Korea.
BK21plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, Korea.
Sci Rep. 2023 Aug 28;13(1):14078. doi: 10.1038/s41598-023-41009-4.
To evaluate the associations of periodontal disease (PD) with systemic diseases, including diabetes mellitus (DM) and cardiovascular disease (CVD), as well as the reciprocal association. The CVD included the cases of coronary heart disease and heart failure. A prospective study was conducted from 2007 to 2019 using linked data from three databases in Korea. Three separate study groups were formed to individually determine the risks of PD (n = 10,533), DM (n = 14,523) and CVD (n = 14,315). All diseases were confirmed based on physicians' diagnoses using medical records and self-reports. Cox proportional hazard regression was applied with 95% confidence intervals (CIs) to obtain hazard ratios (HRs). PD was significantly associated with an elevated risk of DM (HR [95% CI]: 1.22 [1.07-1.39]) after full adjustment for age, sex, lifestyle factors, body mass index, dental behaviour and CVD. PD was also found to increase the risk of CVD (1.27 [1.03-1.57]), whereas CVD increased the risk of PD (1.20 [1.09-1.32]) after full adjustment for other covariates including DM. This study found a bidirectional association between PD and CVD, as well as a positive association of PD with DM.
为了评估牙周病（PD）与包括糖尿病（DM）和心血管疾病（CVD）在内的系统性疾病之间的关联，以及相互关联。CVD 包括冠心病和心力衰竭病例。本前瞻性研究于 2007 年至 2019 年期间，使用韩国三个数据库的关联数据进行。为了分别确定 PD（n=10533）、DM（n=14523）和 CVD（n=14315）的风险，形成了三个单独的研究组。所有疾病均根据医生使用病历和自我报告的诊断进行确认。应用 Cox 比例风险回归，获得了危险比（HR）及其 95%置信区间（CI）。在充分调整年龄、性别、生活方式因素、体重指数、口腔行为和 CVD 后，PD 与 DM 风险升高显著相关（HR [95%CI]：1.22 [1.07-1.39]）。PD 也被发现增加 CVD 的风险（1.27 [1.03-1.57]），而在充分调整包括 DM 在内的其他混杂因素后，CVD 增加 PD 的风险（1.20 [1.09-1.32]）。本研究发现 PD 与 CVD 之间存在双向关联，以及 PD 与 DM 之间存在正相关。
