Longgang Ear-Nose-Throat (ENT) Hospital, Institute of Ear-Nose-Throat (ENT) and Shenzhen Key Laboratory of Ear-Nose-Throat (ENT), Shenzhen, China.
Shenzhen Longgang Institute of Stomatology, Longgang Ear-Nose-Throat (ENT) Hospital, Shenzhen, China.
Front Endocrinol (Lausanne). 2023 Dec 5;14:1292596. doi: 10.3389/fendo.2023.1292596. eCollection 2023.
It has been well documented that there is a two-way relationship between diabetes mellitus and periodontitis. Diabetes mellitus represents an established risk factor for chronic periodontitis. Conversely, chronic periodontitis adversely modulates serum glucose levels in diabetic patients. Activated immune and inflammatory responses are noted during diabetes and periodontitis, under the modulation of similar biological mediators. These activated responses result in increased activity of certain immune-inflammatory mediators including adipokines and microRNAs in diabetic patients with periodontal disease. Notably, certain microbes in the oral cavity were identified to be involved in the occurrence of diabetes and periodontitis. In other words, these immune-inflammatory mediators and microbes may potentially serve as biomarkers for risk assessment and therapy selection in diabetes and periodontitis. In this review, we briefly provide an updated overview on different potential biomarkers, providing novel diagnostic and therapeutic insights on periodontal complications and diabetes mellitus.
有大量文献记载糖尿病和牙周炎之间存在双向关系。糖尿病代表慢性牙周炎的既定危险因素。相反，慢性牙周炎会使糖尿病患者的血清葡萄糖水平发生不利变化。在糖尿病和牙周炎期间，会出现激活的免疫和炎症反应，这些反应受相似的生物介质调节。这些激活的反应导致某些免疫炎症介质的活性增加，包括糖尿病伴牙周病患者的脂肪因子和 microRNAs。值得注意的是，口腔中的某些微生物被认为与糖尿病和牙周炎的发生有关。换句话说，这些免疫炎症介质和微生物可能潜在地作为糖尿病和牙周炎风险评估和治疗选择的生物标志物。在这篇综述中，我们简要提供了不同潜在生物标志物的最新概述，为牙周并发症和糖尿病提供了新的诊断和治疗见解。
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