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苦参碱衍生物YF-18通过下调Skp2抑制肺癌细胞的增殖和迁移。

Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2.

作者信息

Wu Lichuan, Wang Guizhen, Wei Jinrui, Huang Na, Zhang Sen, Yang Fangfang, Li Ming, Zhou Guangbiao, Wang Lisheng

机构信息

School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, PR China.

State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.

出版信息

Oncotarget. 2017 Feb 14;8(7):11729-11738. doi: 10.18632/oncotarget.14329.

DOI:10.18632/oncotarget.14329
PMID:28036296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5355299/
Abstract

Lung cancer is the leading cause of cancer related death which needs novel drugs to improve patient outcomes. In this study, we examined the ability of YF-18, a novel matrine derivative to inhibit the growth and migration of lung cancer cells. By cell cycle analysis, wound healing and transwell assays, we found that YF-18 induced G2/M cell cycle arrest and inhibited migration of lung cancer cells in a dose-dependent manner. Further results indicated that YF-18 inhibited cell proliferation and migration through down-regulating Skp2 and up-regulating its substrates, p27 and E-cadherin. Moreover, YF-18 inhibited A549-luciferase cell xenograft tumor growth in a dose-dependent manner. The findings indicate that YF-18 bears therapeutic potentials for lung cancer.

摘要

肺癌是癌症相关死亡的主要原因，需要新型药物来改善患者预后。在本研究中，我们检测了新型苦参碱衍生物YF-18抑制肺癌细胞生长和迁移的能力。通过细胞周期分析、伤口愈合实验和Transwell实验，我们发现YF-18以剂量依赖的方式诱导G2/M期细胞周期阻滞并抑制肺癌细胞的迁移。进一步的结果表明，YF-18通过下调Skp2并上调其底物p27和E-钙黏蛋白来抑制细胞增殖和迁移。此外，YF-18以剂量依赖的方式抑制A549-荧光素酶细胞异种移植瘤的生长。这些发现表明YF-18对肺癌具有治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/64ab91c7257b/oncotarget-08-11729-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/d7a6ddc0ae57/oncotarget-08-11729-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/413e2e66b738/oncotarget-08-11729-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/ab4c255753a7/oncotarget-08-11729-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/a04384018927/oncotarget-08-11729-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/923313691686/oncotarget-08-11729-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/64ab91c7257b/oncotarget-08-11729-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/d7a6ddc0ae57/oncotarget-08-11729-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/413e2e66b738/oncotarget-08-11729-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/ab4c255753a7/oncotarget-08-11729-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/a04384018927/oncotarget-08-11729-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/923313691686/oncotarget-08-11729-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2583/5355299/64ab91c7257b/oncotarget-08-11729-g006.jpg

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本文引用的文献

1
World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015.《2014年世界癌症报告》。瑞士日内瓦：世界卫生组织、国际癌症研究机构，世卫组织出版社，2015年。
Adv Nutr. 2016 Mar 15;7(2):418-9. doi: 10.3945/an.116.012211. Print 2016 Mar.
2
The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution.与环境多环芳烃污染相关的肺癌中的趋化因子CXCL13
Elife. 2015 Nov 13;4:e09419. doi: 10.7554/eLife.09419.
3
Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway.
钙激活氯离子通道 ANO1（TMEM16A）的功能和调节。
Handb Exp Pharmacol. 2024;283:101-151. doi: 10.1007/164_2022_592.
4
Design, Synthesis, Molecular Docking, and Tumor Resistance Reversal Activity Evaluation of Matrine Derivative with Thiophene Structure.具有噻吩结构的苦参碱衍生物的设计、合成、分子对接及肿瘤耐药逆转活性评价。
Molecules. 2021 Jan 14;26(2):417. doi: 10.3390/molecules26020417.
5
Mechanisms of Compound Kushen Injection for the Treatment of Lung Cancer Based on Network Pharmacology.基于网络药理学的复方苦参注射液治疗肺癌的作用机制
Evid Based Complement Alternat Med. 2019 May 28;2019:4637839. doi: 10.1155/2019/4637839. eCollection 2019.
6
Matrine inhibits TPC-1 human thyroid cancer cells via the miR-21/PTEN/Akt pathway.苦参碱通过miR-21/PTEN/Akt信号通路抑制人甲状腺癌细胞TPC-1。
Oncol Lett. 2018 Sep;16(3):2965-2970. doi: 10.3892/ol.2018.9006. Epub 2018 Jun 21.
7
Matrine inhibits the proliferation and migration of lung cancer cells through regulation of the protein kinase B/glycogen synthase kinase-3β signaling pathways.苦参碱通过调控蛋白激酶B/糖原合成酶激酶-3β信号通路抑制肺癌细胞的增殖和迁移。
Exp Ther Med. 2018 Aug;16(2):723-729. doi: 10.3892/etm.2018.6266. Epub 2018 Jun 7.
8
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J Immunol Res. 2018 Jan 10;2018:5408324. doi: 10.1155/2018/5408324. eCollection 2018.
9
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Curr Top Dev Biol. 2015;112:273-300. doi: 10.1016/bs.ctdb.2014.11.021. Epub 2015 Feb 11.
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J Cell Biol. 2014 Oct 27;207(2):181-8. doi: 10.1083/jcb.201408044.
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ACS Med Chem Lett. 2013 Aug 12;4(10):921-6. doi: 10.1021/ml400093y. eCollection 2013 Oct 10.
10
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Am J Chin Med. 2014;42(3):543-59. doi: 10.1142/S0192415X14500359.